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Neural mechanisms of ultrasound-induced enhancement of sensory acuity

Award Number: R01EB028319
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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Neural mechanisms of ultrasound-induced enhancement of sensory acuity - Project Summary/Abstract Representational plasticity in the cerebral cortex is a dramatic example of the brain’s accommodative response to injury or training. An emerging approach for rehabilitating, and potentially enhancing, sensation involves the use of noninvasive, transcranially-directed focused ultrasound (FUS) to directly affect neural function. Compared with other noninvasive neuromodulation techniques applicable to humans, FUS offers the possibility of modulating neural activity with superior spatial resolution even for targets deep within the brain. Despite the allure of FUS as a modulation approach, many aspects of the technology relevant to translational capability are unclear, and conflicting results have been reported for even macroscopic effects. In order to fully leverage the use of FUS for rehabilitative or augmentative purposes in humans, the impact on behavior must be well characterized and robust. Characterizing the transformation of targeted stimulation to behavioral changes therefore requires a combination of new experimental approaches for (1) monitoring the direct neural effects of targeted stimulation in the brain, and (2) monitoring quantitative behavioral readouts in the same animal. By leveraging novel optical tools and behavioral experimental approaches, the proposed research will address key knowledge gaps that currently limit development and refinement of FUS neuromodulation for use in humans. Because the Aims collectively connect neural mechanisms with behavior, this work would represent a significant step toward the potentially transformative prospect of customized sensory modulation for therapeutic or augmentative applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	NEW YORK MEDICAL COLLEGE	40 SUNSHINE COTTAGE RD	VALHALLA	NY	10595	WESTCHESTER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	5/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	NEW YORK MEDICAL COLLEGE	40 SUNSHINE COTTAGE RD	VALHALLA	NY	10595	WESTCHESTER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	2/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $335,608 )
2023	2023	NEW YORK MEDICAL COLLEGE	40 SUNSHINE COTTAGE RD	VALHALLA	NY	10595	WESTCHESTER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	1/30/2023	NON-COMPETING CONTINUATION	$335,608
														Subtotal = $335,608

Issue Date FY: 2022 ( Subtotal = $343,143 )
2022	2022	NEW YORK MEDICAL COLLEGE	40 SUNSHINE COTTAGE RD	VALHALLA	NY	10595	WESTCHESTER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	6/29/2022	NON-COMPETING CONTINUATION	$34,316
2022	2022	NEW YORK MEDICAL COLLEGE	40 SUNSHINE COTTAGE RD	VALHALLA	NY	10595	WESTCHESTER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	1/28/2022	NON-COMPETING CONTINUATION	$308,827
														Subtotal = $343,143

Issue Date FY: 2021 ( Subtotal = $336,807 )
2021	2021	NEW YORK MEDICAL COLLEGE	40 SUNSHINE COTTAGE RD	VALHALLA	NY	10595	WESTCHESTER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	5/26/2021	NON-COMPETING CONTINUATION	$0
2021	2021	NEW YORK MEDICAL COLLEGE	40 SUNSHINE COTTAGE RD	VALHALLA	NY	10595	WESTCHESTER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/17/2021	NON-COMPETING CONTINUATION	$336,807
														Subtotal = $336,807

Issue Date FY: 2020 ( Subtotal = $352,239 )
2020	2020	NEW YORK MEDICAL COLLEGE	40 SUNSHINE COTTAGE RD	VALHALLA	NY	10595	WESTCHESTER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	3/25/2020	NEW	$352,239
														Subtotal = $352,239

Grand Total All Awards = $1,367,797

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Neural mechanisms of ultrasound-induced enhancement of sensory acuity

Award Number: R01EB028319

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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