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Ultra-Resolution Imaging on Standard Clinical CT

Award Number: R01EB028270
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/02/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Ultra-Resolution Imaging on Standard Clinical CT - PROJECT SUMMARY/ABSTRACT Despite great strides in improving the volume coverage, temporal resolution, and dose efficiency of clinical CT scanners, the spatial resolution has plateaued since the mid-1980s. Nevertheless, there is a clear clinical need to reveal a new level of anatomic detail for CT imaging in multiple areas, including assessment of bone fractures, bone microarchitecture and fracture risk, spinal stenosis, spinal fusion healing after surgery, and cochlear im- plant placement. Various attempts have been made to improve the spatial resolution of CT, but the improvements have been incremental and there is still no practical solution that can enable in vivo ultra-resolution imaging on standard clinical CT scanners: a redesign of the CT detector array to one with finer pitched cells is very expensive for widespread application, while high-resolution extremity CT and flat-panel CT have limited bore size and suffer from inherent image quality issues, respectively. We propose a new ultra-resolution CT technique, named “Zoomed-In Partial Scan” (ZIPS), to achieve a ma- jor improvement in the spatial resolution of standard, clinical CT. The increased spatial resolution is achieved by combining an extra small focal spot with a large magnification, and with innovative scanning schemes and re- construction algorithms. The ZIPS method can be incorporated on existing standard clinical CT scanners, with- out a costly redesign of the CT detector based on smaller cells or sacrificing image quality or dose efficiency in regular scans. Compared with various specialized high-resolution research CT scanners, the proposed ZIPS method leverages the accessibility, versatility, and wide volume coverage of standard clinical CT to provide an in vivo ultra-resolution option for a wide patient population and various anatomical regions. The project combines CT systems and reconstruction expertise at GE Research Center and clinical applica- tion expertise at the Hospital for Special Surgery (HSS) and the Massachusetts Eye and Ear Institute (MEEI). The GE Research Center team will perform all technical developments of this project. The HSS team will lead an ex vivo validation study of the ZIPS CT technique applied to bone microstructure analysis, and compare results with µCT gold standard and standard clinical CT. MEEI will provide clinical expertise in the evaluation of ZIPS CT for temporal bone imaging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	1/14/2025	NON-COMPETING CONTINUATION	-$118,364
2025	2022	GE MEDICAL SYSTEMS INFORMATION TECHNOLOGIES, INC.	1 RESEARCH CIR BLDG K-1	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	4	1/14/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$120,655
2025	2021	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	1/14/2025	NON-COMPETING CONTINUATION	-$2,291
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	12/21/2023	NON-COMPETING CONTINUATION	-$238,717
2024	2022	GE MEDICAL SYSTEMS INFORMATION TECHNOLOGIES, INC.	1 RESEARCH CIR BLDG K-1	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	12/22/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$238,717
2024	2022	GE MEDICAL SYSTEMS INFORMATION TECHNOLOGIES, INC.	1 RESEARCH CIR BLDG K-1	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	4	5/23/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $357,081 )
2022	2022	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	6/13/2022	NON-COMPETING CONTINUATION	$357,081
														Subtotal = $357,081

Issue Date FY: 2021 ( Subtotal = $720,202 )
2021	2021	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/24/2021	NON-COMPETING CONTINUATION	$720,202
														Subtotal = $720,202

Issue Date FY: 2020 ( Subtotal = $632,848 )
2020	2020	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	7/30/2020	NEW	$574,233
2020	2020	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	9/22/2020	NEW	$58,615
														Subtotal = $632,848

Grand Total All Awards = $1,710,131

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Ultra-Resolution Imaging on Standard Clinical CT

Award Number: R01EB028270

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/02/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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