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Application of the principle of symmetry to neural circuitry: From building blocks to neural synchronization in the connectome

Award Number: R01EB028157
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/08/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Application of the principle of symmetry to neural circuitry: From building blocks to neural synchronization in the connectome - Project Summary/Abstract The broad, long-term objective of this grant is to advance a new theoretical approach to identify synchronized building blocks of neural circuits based on group theory and its application to understand the permutation symmetries of these circuits. Based on the developed theoretical framework we will validate our theory by probing brain dynamics at single-cell resolution and in real-time, i.e. sub-second scale, in C. elegans, which is a system with a fully mapped synapse-resolution connectome. We will produce a software tool that will allow end-users from the broad neuroscience community to identify and analyze the building blocks of neural circuits and explore their relation with function. Speciﬁc Aims are: · Speciﬁc Aim 1. Develop a generalized theoretical framework of symmetry groups and their unique decomposition into normal subgroups to identify building blocks made of synchronized neural pop- ulations in brain networks. Based on our preliminary work in locomotion in C. elegans, we will evaluate the application of symmetry groups to more complex functions and more complex neural systems of other species to investigate the relation between symmetries of the connectome and neural synchronization. · Speciﬁc Aim 2. Verify experimentally the predicted building blocks in C. elegans nervous system with system-wide Ca2+-imaging experiments. We will develop an experimental program to test the predictions of the theory on the synchronization of neural populations identiﬁed by symmetry groups, and the subsequent breaking of symmetry and asynchrony tested by single-cell laser ablation. · Speciﬁc Aim 3. Resource sharing plan and software development: Develop software and tools based on the algorithms developed in Aim 1 and evaluated in Aim 2 to identify the building blocks of neural circuits to study their synchronization and function. Optimize the usability of the software by experimentalists (end-user PD Manuel Zimmer) and other researchers for use in the larger scientiﬁc community. Long term goals: The results of the present study should lead to improve our understanding of the designing principles of neural circuits and how this structure inﬂuences function. Once completed, we trust that the tools developed by this project will be able to be used by the larger neuroscience community to study the building blocks of all connectomes. The development of theories of the organization of the connectome should lead to the inference of general principles regarding network organization applicable to areas outside neuroscience that include information processing complex systems in general.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$422 )
2026	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	10/1/2025	NEW	-$422
														Subtotal = -$422

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	7/31/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	7/6/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,064,970 )
2020	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/8/2020	NEW	$1,064,970
														Subtotal = $1,064,970

Grand Total All Awards = $1,064,548

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Application of the principle of symmetry to neural circuitry: From building blocks to neural synchronization in the connectome

Award Number: R01EB028157

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/08/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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