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Enabling Brain Parametric Imaging of Alzheimer's disease with an Organ-dedicated PET

Award Number: R01EB028091
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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Enabling Brain Parametric Imaging of Alzheimer's disease with an Organ-dedicated PET - ABSTRACT Dynamic positron emission tomography (PET) imaging with tracer kinetic modeling has the potential to enable quantitative characterization of Alzheimer’s disease and related dementias (ADRD) but suffers from invasive blood sampling and limited spatial resolution for imaging small brain vasculature. The high volumetric resolution (~1 mm3) technology being developed under our R01 “High Spatial Resolution Dedicated Head and Neck PET System based on Cadmium Zinc Telluride” can innovatively be applied to improving ADRD imaging efforts. In this ADRD-supplement, we will augment our novel technology for brain imaging and also develop an optimization-derived input function method (ODIF) to enable our scanner to provide accurate dynamic PET imaging of ADRD and offer clinical insight into early detection of ADRD and the quantification of radiotracer concentrations; resulting in imaging that is less invasive and more accurate. Thus far, our scanner from the R01, has demonstrated a depth of interaction <1 mm, high multiple interaction photon event recovery (accuracy >86%), and fully-functional low-noise in-house readout electronics (trigger on energies above 15 keV with electronic noise of 1% FWHM measured by test pulse injecting charge equivalent of 511 keV). These features minimize the spillover and partial volume effects and improve the carotid-derived input function for brain kinetic quantification. The ODIF method will have the potential to further improve the performance of our dedicated system and it can be applied to many existing brain-dedicated scanners and clinical scanners for ADRD imaging. Therefore, our ultra-high resolution and modular design with high packing fraction (~99%) is excellently positioned to improve ADRD imaging as we will add a neck imager to brain-dedicated systems and have high- quality imaging output.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$52,608 )
2025	2021	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	1/31/2025	NON-COMPETING CONTINUATION	-$32,935
2025	2021	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	1/31/2025	SUPPLEMENT FOR EXPANSION	-$19,673
														Subtotal = -$52,608

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	9/18/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	9/18/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $795,316 )
2021	2021	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	6/10/2021	SUPPLEMENT FOR EXPANSION	$297,415
2021	2021	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/9/2021	NON-COMPETING CONTINUATION	$497,901
														Subtotal = $795,316

Issue Date FY: 2020 ( Subtotal = $666,108 )
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	6/19/2020	NON-COMPETING CONTINUATION	$666,108
2020	2019	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	6/18/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$87,356
2020	2018	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/18/2020	NEW	-$87,356
														Subtotal = $666,108

Issue Date FY: 2019 ( Subtotal = $640,957 )
2019	2019	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	8/12/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$640,957
2019	2018	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/12/2019	NEW	$0
														Subtotal = $640,957

Issue Date FY: 2018 ( Subtotal = $540,510 )
2018	2018	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST STE 364	URBANA	IL	61801	CHAMPAIGN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/20/2018	NEW	$540,510
														Subtotal = $540,510

Grand Total All Awards = $2,590,283

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Enabling Brain Parametric Imaging of Alzheimer's disease with an Organ-dedicated PET

Award Number: R01EB028091

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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