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Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapy

Award Number: R01EB027705
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapy - Project Summary Overcoming the poor efficacy of tumor cell vaccines will require enhancing activation of the immune system and preventing an immunosuppressive tumor microenvironment such as local hypoxia. In this proposal, we will address this critical need by engineering tumor cell vaccines with advanced oxygen-releasing biomaterials (O2- cryogels) to combat hypoxia-driven immunosuppression and improve antitumor immune responses in relevant mouse models of prostate cancer. Our preliminary data in mice indicate that: (i) O2-cryogels can reverse local hypoxia and restore the function of key immune cells (dendritic cells; DCs); (ii) once in the body, cryogel vaccines efficiently localize transplanted tumor cells, controllably release immunomodulatory factors, and recruit large numbers of DCs from the host; and (iii) elicit a specific and robust vaccine-induced T cell-mediated antitumor immunity. Here, we will optimize the characteristics of O2-cryogels for maximum antitumor efficacy and safety; and assess their ability to suppress the local hypoxic stress and improve DC recruitment, activation, and homing to the draining lymph nodes. Finally, we will test O2-cryogel vaccines in prophylactic and therapeutic mouse models of prostate cancer to determine their ability to induce specific, effective, and long-lasting antitumor immune responses. This proposal may have a sustained impact on the field by defining a new avenue of cancer immunotherapy that operates independently but synergizes with other therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $441,967 )
2024	2024	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	4/30/2024	NON-COMPETING CONTINUATION	$441,967
2024	2023	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	1/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $441,967

Issue Date FY: 2023 ( Subtotal = $450,986 )
2023	2023	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	3/31/2023	NON-COMPETING CONTINUATION	$450,986
														Subtotal = $450,986

Issue Date FY: 2022 ( Subtotal = $471,003 )
2022	2022	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	4/20/2022	NON-COMPETING CONTINUATION	$471,003
														Subtotal = $471,003

Issue Date FY: 2021 ( Subtotal = $488,344 )
2021	2021	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/28/2021	NEW	$488,344
														Subtotal = $488,344

Grand Total All Awards = $1,852,300

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Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapy

Award Number: R01EB027705

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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