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BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging

Award Number: R01EB026299
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Electrophysiological recordings in humans and animals play an essential role in developing an understanding of the human brain. Signal recording technology spans the entire scale from invasive microelectrode single-unit recordings, through mesoscale macroelectrode measures of local field potentials, to whole-brain monitoring through measurement of scalp potentials (EEG) and extracranial magnetic fields (MEG). Analysis of these data presents a host of challenges, from low level noise removal and artifact rejection to sophisticated spatio-temporal modeling and statistical inference. The multidisciplinary neuroscience research community has an ongoing need for validated and documented open-source software to perform this analysis and to facilitate reproducible and large-scale research involving electrophysiological data. This proposal describes our plans to continue to develop and support Brainstorm, open-source software that meets this need. Brainstorm is a Matlab/Java multi-platform (Linux, MacOS, Windows) software package for analysis and visualization of electrophysiological data. The software is extensively documented through a series of detailed tutorials and actively supported through a user forum and a mailing list. Over the past 8 years we have registered 16,000 distinct users, provided hands on instruction to 1,200 trainees, and the software has been used and cited in ~600 journal papers. Brainstorm includes tools for importing MEG/EEG, intracranial EEG, animal electrophysiology, and near-infrared spectroscopy (NIRS) data from multiple vendors, extensive interactive features for data preprocessing, selection and visualization, coregistration to volume and surface MRIs and atlases, forward and inverse mapping of cortical current density, time-series and connectivity analysis, and a range of statistical tools. Data can be analyzed through a graphical interface or through scripted pipelines. The current proposal represents a plan to extend Brainstorm in a manner that leverages the unique features of our software and addresses important needs for large-scale data analysis. In this project we will continue to extend and support our software through the following three specific aims: (i) we will harness recent developments in distributed and shared data and high performance computing resources, together with standardization of data organization, to facilitate large-scale, reproducible analysis of electrophysiological data. (ii) We will also address the need for improved modeling resulting from the increasing use of both invasive recordings and direct brain stimulation through development of new modeling software for accurate computation of the intracranial electromagnetic fields produced by brain stimulation and neuronal activation. (iii) Finally, we will continue to add new functionality and to support the software through in-person training, online forums, documentation and other resources.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $990,192 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	6	4/21/2023	NON-COMPETING CONTINUATION	$617,640
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	6	5/29/2023	SUPPLEMENT FOR EXPANSION	$372,552
2023	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	3/22/2023	COMPETING CONTINUATION	$33,609
2023	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	11/1/2022	COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	3/22/2023	NON-COMPETING CONTINUATION	-$33,609
														Subtotal = $990,192

Issue Date FY: 2022 ( Subtotal = $650,138 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	6/27/2022	COMPETING CONTINUATION	$650,138
2022	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	6/17/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	5/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $650,138

Issue Date FY: 2021 ( Subtotal = $616,433 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	3/20/2021	NON-COMPETING CONTINUATION	$616,433
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	5/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $616,433

Issue Date FY: 2020 ( Subtotal = $633,469 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	2/24/2020	NON-COMPETING CONTINUATION	$633,469
														Subtotal = $633,469

Issue Date FY: 2019 ( Subtotal = $637,924 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/14/2019	NON-COMPETING CONTINUATION	$637,924
														Subtotal = $637,924

Issue Date FY: 2018 ( Subtotal = $678,920 )
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/12/2018	NEW	$678,920
														Subtotal = $678,920

Grand Total All Awards = $4,207,076

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BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging

Award Number: R01EB026299

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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