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BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging

Award Number: R01EB026299
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2018
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging - PROJECT SUMMARY / ABSTRACT Brainstorm is a Matlab/Java multi-platform (Linux, MacOS, Windows) software environment for analysis and visualization of electrophysiological (e-phys) data. While originally focused on noninvasive EEG and MEG, Brainstorm now also includes tools for analysis and advanced visualization of a broader range of data modalities: intracranial EEG including ECOG, SEEG macroelectrode recordings, MUA and LFP microelectrode data in humans and in-vitro/in-vivo preparations in animal models, and noninvasive NIRS data. The software is widely used and plays an increasingly important role in clinical and cognitive neuroscience research as reflected in the following statistics over the past decade: 1,700 published articles reporting analyses performed with Brainstorm, 30,000 user accounts, 34,000 posts on the online user forum, and 2,000 students, postdocs and faculty around the globe have attended in-person or online Brainstorm training events. Over the past four years we have built on the extensive capabilities of Brainstorm by defining and implementing a BIDS-compatible database structure and adding tools for cloud/advanced computing over distributed data resources. We have added improved interfaces with other EEG/MEG software, leading spike-sorting e-phys software, and hardware (including the ability to import from multiple commercial file data formats). We have also added interoperability with MRI- analysis software and deployed tools for FEM-based head modeling. Under this renewal we will address the following: Aim 1: Enabling Tools for Naturalistic and Single-Trial Neurophysiology Studies: There is increasing scientific interest in eliciting, recording, and analyzing neural responses to non-repetitive and naturalistic stimuli. Data of this type present particular challenges in terms of documenting rigorously varied, uncontrolled sensory events and behavioral responses with machine and human readable annotations, and relating such complex sensory presentations and behavior to measured brain activity. We will therefore develop a suite of tools for preparing and analyzing multimodal e-phys data in the context of naturalistic neuroscience. Aim2: Tools for Invasive Recordings: We will build on developments in the current project period to provide tools for preprocessing and analysis of invasive recordings and FEM-based modeling of intracranial current fields including labelling, localization and co-registration of complex iEEG electrode montages from X-ray CT to MRI, automated identification and tagging of interictal features in iEEG, and characterization, localization and validation of neuronal sources from iEEG. Aim 3: Software Enhancement, Integration, Maintenance, Training, and Documentation: We will pursue a three-pronged development track: (i) a hub-based framework in which third-party tools can be linked, run and with results visualized entirely from Brainstorm as a hub; (ii) build on our existing provenance tools so that users can save analysis histories to allow full reproducibility; and (iii) provide links and interoperability with statistical packages to promote rigor. We will continue to develop Brainstorm with multiplatform compatibility, web-based documentation, user forums, and hands-on training.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $555,876 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	3/21/2025	NON-COMPETING CONTINUATION	$555,876
														Subtotal = $555,876

Issue Date FY: 2024 ( Subtotal = $605,288 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	5/6/2024	NON-COMPETING CONTINUATION	$605,288
														Subtotal = $605,288

Issue Date FY: 2023 ( Subtotal = $990,192 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	6	5/29/2023	SUPPLEMENT FOR EXPANSION	$372,552
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	6	4/21/2023	NON-COMPETING CONTINUATION	$617,640
2023	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	11/1/2022	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	3/22/2023	COMPETING CONTINUATION	$33,609
2023	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	3/22/2023	NON-COMPETING CONTINUATION	-$33,609
														Subtotal = $990,192

Issue Date FY: 2022 ( Subtotal = $650,138 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	6/27/2022	COMPETING CONTINUATION	$650,138
2022	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	6/17/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	5/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $650,138

Issue Date FY: 2021 ( Subtotal = $616,433 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	3/20/2021	NON-COMPETING CONTINUATION	$616,433
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	5/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $616,433

Issue Date FY: 2020 ( Subtotal = $633,469 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	2/24/2020	NON-COMPETING CONTINUATION	$633,469
														Subtotal = $633,469

Issue Date FY: 2019 ( Subtotal = $637,924 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/14/2019	NON-COMPETING CONTINUATION	$637,924
														Subtotal = $637,924

Issue Date FY: 2018 ( Subtotal = $678,920 )
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/12/2018	NEW	$678,920
														Subtotal = $678,920

Grand Total All Awards = $5,368,240

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BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging

Award Number: R01EB026299

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2018

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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