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In Vivo Therapeutic Cell Tracking by Advanced Magnetic Particle Imaging

Award Number: R01EB024578
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2017
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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In Vivo Therapeutic Cell Tracking by Advanced Magnetic Particle Imaging - Abstract Cell therapies have been held back by serious challenges in achieving speciﬁc delivery to the damaged organ, realizing treatment efﬁcacy, and safety concerns. A noninvasive imaging technique that could follow a sub-therapeutic dose (say 10 cells) anywhere in the body, and report back on the cells' viability, could greatly expedite protocol optimization and hasten cellular therapy clinical adoption. Today's whole-animal cell tracking imaging methods (e.g., MRI, optical, ultrasound, nuclear medicine) all have their strengths and technical limitations. A new noninvasive imaging method called Magnetic Particle Imaging (MPI) uses zero radiation. MPI shows extraordinary promise as a complementary cell tracking and reporting method. Just to be clear, MPI images cannot be obtained in an MRI scanner. This year, our group at Berkeley showed MPI tracking of stem cells for the ﬁrst time in live animals, with quantitative 200-cell “positive contrast” sensitivity. MPI shows ideal, quantitative contrast with no confounds near air or bone as in other modalities. MPI is already 100-times more sensitive than today's noninvasive cell imaging methods, and here we aim to make it even more sensitive. Both the 200-cell sensitivity and MPI's spatial resolution can still be greatly improved. Our overall aim is to improve MPI to reach the true physics limits of MPI, speciﬁcally 20-cell detection and 280-micron spatial resolution. Finally, we plan to validate these innovations by tracking an in vivo model of stem cell treatment for demyelinating disease with stem cell expert, UC Berkeley Professor David Schaffer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$10,899 )
2023	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	11/21/2022	NON-COMPETING CONTINUATION	-$10,899
														Subtotal = -$10,899

Issue Date FY: 2020 ( Subtotal = $485,634 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/3/2020	NON-COMPETING CONTINUATION	$485,634
														Subtotal = $485,634

Issue Date FY: 2019 ( Subtotal = $786,227 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/16/2019	NON-COMPETING CONTINUATION	$485,634
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	9/4/2019	SUPPLEMENT FOR EXPANSION	$300,593
														Subtotal = $786,227

Issue Date FY: 2018 ( Subtotal = $485,634 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/5/2018	NON-COMPETING CONTINUATION	$485,634
														Subtotal = $485,634

Issue Date FY: 2017 ( Subtotal = $485,634 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	7/28/2017	NEW	$485,634
														Subtotal = $485,634

Grand Total All Awards = $2,232,230

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In Vivo Therapeutic Cell Tracking by Advanced Magnetic Particle Imaging

Award Number: R01EB024578

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2017

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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