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Surface-Based Fiber Tracking and Modeling Techniques for Mapping the Superficial White Matter Connectome with Diffusion MRI

Award Number: R01EB022744
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Surface-Based Fiber Tracking and Modeling Techniques for Mapping the Superficial White Matter Connectome with Diffusion MRI - Abstract The superficial white matter (SWM) lies directly beneath the cortex and contains the short association fibers, or U-fibers, connecting neighboring gyri. The SWM contains around twice as many fiber connections as the deep white matter (DWM) and plays a crucial role in brain development, aging, and various brain disorders. Existing connectome imaging research based on diffusion MRI (dMRI), however, mostly focuses on the connections of long fiber bundles in the DWM even though tremendous advances have been made in human connectome imaging with much improved spatial and angular resolution. In this proposed renewal of our R01 project (NIBIB R01EB022744), we will conduct systematic development of novel computational tools to fill major technical gaps in current SWM research. Our project will provide fundamentally novel solutions to many of the current challenges in SWM connectome research by developing surface-based tools for fiber tracking, atlas construction, and personalized analysis. We will also develop novel personalized dMRI harmonization methods with a particular focus on accounting for the variable cortical anatomy. These developments will for the first time provide dedicated tools for modeling SWM connectome with greatly improved robustness and accuracy. There are three specific aims in our project: 1. Development of novel surface-based fiber tracking and filtering algorithms for the modeling of superficial white matter connectivity. 2. Development of surface-based U-fiber atlases and personalized SWM connectivity analysis. 3. Development of personalized diffusion MRI harmonization tools with improved consistency in cortical anatomy. Rigorous validations of our novel surface-based U-fiber tracking and modeling methods will be performed on high-resolution MRI of post-mortem brains, in vivo intracranial neural recordings from surgically implanted electrodes in patients with epilepsy, and their application in multiple large- scale connectome imaging datasets (n>5000). All software tools and atlases developed in this project will be publicly shared, which will allow brain imaging researchers to augment their current connectome models with U- fibers in SWM and more completely map human brain connectomes for the detection of their alterations in various brain disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	2/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $541,242 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	6	6/7/2024	NON-COMPETING CONTINUATION	$44,182
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	6	3/1/2024	NON-COMPETING CONTINUATION	$497,060
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	2/28/2024	COMPETING CONTINUATION	$56,865
2024	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	2/28/2024	NON-COMPETING CONTINUATION	-$56,865
														Subtotal = $541,242

Issue Date FY: 2023 ( Subtotal = $562,847 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	5/1/2023	COMPETING CONTINUATION	$562,847
2023	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $562,847

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $390,773 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/18/2019	NON-COMPETING CONTINUATION	$390,773
														Subtotal = $390,773

Issue Date FY: 2018 ( Subtotal = $659,900 )
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	9/1/2018	SUPPLEMENT FOR EXPANSION	$269,127
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	9/5/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	8/22/2018	NON-COMPETING CONTINUATION	$390,773
														Subtotal = $659,900

Issue Date FY: 2017 ( Subtotal = $555,773 )
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	9/21/2017	SUPPLEMENT FOR EXPANSION	$165,000
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/13/2017	NON-COMPETING CONTINUATION	$390,773
														Subtotal = $555,773

Issue Date FY: 2016 ( Subtotal = $402,653 )
2016	2016	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/22/2016	NEW	$402,653
														Subtotal = $402,653

Grand Total All Awards = $3,113,188

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Surface-Based Fiber Tracking and Modeling Techniques for Mapping the Superficial White Matter Connectome with Diffusion MRI

Award Number: R01EB022744

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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