Friday, April 19, 2024 4/19/2024

Computational Tools for Modeling Human and Mouse Connectome with Multi-Shell Diffusion Imaging

Award Number: R01EB022744
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

ABSTRACT For the in vivo investigation of brain connectome, diffusion MRI (dMRI) is an important tool as it provides highly sensitive imaging markers and allows the examination of connection paths via tractography. With the success of the Human Connectome Project (HCP), high resolution, multi-shell diffusion imaging is emerging as the standard approach for dMRI data acquisition in connectome studies. To fully unleash the potential of multi-shell dMRI, in this project we will develop a suite of novel computational tools that jointly estimate fiber orientation distributions (FOD) and compartmental parameters. With FOD-based tractography, we can reliably resolve crossing fibers and reconstruct fiber bundles that faithfully follow known anatomy such as the retinotopy of visual pathways. Compartmental parameters provide sensitive imaging markers for studying local cellular environment surrounding the axons. Our tools are generally applicable for both human and mouse connectome research. One main challenge in diffusion tractography is the lack of rigorous validations with biologically meaningful ground truth. With large-scale tracer injection data of mouse brains from the Mouse Connectome Project (MCP) at USC and the Allen Mouse Brain Connectivity Atlas, we will perform a systematic validation and optimization of our FOD-based techniques from the denoising of imaging signals to the configuration of compartment models to the selection of tractography parameters. This will create a well-validated system for studying mouse connectome with multi-shell imaging, and provide intuitive guidelines for the design of human studies with FOD-based connectome. There are three specific aims in our project: 1. To develop a general computational framework for the joint estimation of fiber orientation and compartment models from multi-shell diffusion imaging. 2. To validate and optimize the computational tools using multi-shell dMRI data of mouse brains and axonal projection maps from tracer injections. 3. To develop a comprehensive toolkit for fiber bundle reconstruction from multi-shell dMRI data of human brains. In this project we will apply our software tools to analyze data collected in two disease studies. In the first study, we will focus on the cortico-striato- thalamo-cortical (CSTC) network and examine its connectivity changes in the BTBD3 mouse model of obsessive-compulsive disorder (OCD). In the second study, we will apply our tools to study the relation of retinal impairment and visual pathway integrity via the retinotopy-preserving connectivity between visual areas. All software tools developed in this project will be distributed freely to the research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $497,060 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	6	3/1/2024	NON-COMPETING CONTINUATION	$497,060
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	2/28/2024	COMPETING CONTINUATION	$56,865
2024	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	2/28/2024	NON-COMPETING CONTINUATION	-$56,865
														Subtotal = $497,060

Issue Date FY: 2023 ( Subtotal = $562,847 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	5/1/2023	COMPETING CONTINUATION	$562,847
2023	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $562,847

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $390,773 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/18/2019	NON-COMPETING CONTINUATION	$390,773
														Subtotal = $390,773

Issue Date FY: 2018 ( Subtotal = $659,900 )
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	8/22/2018	NON-COMPETING CONTINUATION	$390,773
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	9/1/2018	SUPPLEMENT FOR EXPANSION	$269,127
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	9/5/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $659,900

Issue Date FY: 2017 ( Subtotal = $555,773 )
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/13/2017	NON-COMPETING CONTINUATION	$390,773
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	9/21/2017	SUPPLEMENT FOR EXPANSION	$165,000
														Subtotal = $555,773

Issue Date FY: 2016 ( Subtotal = $402,653 )
2016	2016	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/22/2016	NEW	$402,653
														Subtotal = $402,653

Grand Total All Awards = $3,069,006

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Computational Tools for Modeling Human and Mouse Connectome with Multi-Shell Diffusion Imaging

Award Number: R01EB022744

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer