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Bio-electrochemical detectors for in vivo continuous monitoring

Award Number: R01EB022015
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Bio-electrochemical detectors for in vivo continuous monitoring - Summary. Our overarching goal is to render therapeutic drug monitoring as convenient and highly time resolved as the continuous glucose monitor has rendered the monitoring of blood sugar. The realization of this goal would transform many aspects of both biomedical research and clinical practice. It would, for example, enable personalized dosing based on a patient’s accurately determined, rather than poorly predicted, drug metabolism, an outcome of high relevance to the treatment of infectious diseases, which commonly employs drugs of dangerously narrow therapeutic index, and to improving women’s health, as pharmacokinetic sex differences lead to a doubling of adverse pharmacotherapeutic outcomes in females. Ultimately such a technology could enable feedback-controlled drug dosing, which, by responding in real time to metabolic variations, would improve the safety and efficacy of drugs that suffer from dose-limiting toxicity. To achieve our goal, however, requires two significant innovations: (1) a technology able to monitor arbitrary drug molecules in situ in the intestinal fluid (ISF) of the subcutaneous space and (2) vastly improved knowledge regarding how the pharmacokinetics of drugs in the ISF relate to the pharmacokinetics seen in plasma. Under the prior round of grant funding, we achieved the first of these necessary advances. Specifically, we demonstrated that minimally-invasive Electrochemical, Aptamer-Based (EAB) sensors support the seconds-resolved, real-time measurement of drugs in situ in the plasma (venous), cerebrospinal fluid (brain), and ISF (subcutaneous space) of our live rat animal model. Here we propose to tackle the second innovation. That is, using intravenous and subcutaneous EAB sensors we propose to advance understanding of the relationships between plasma and ISF pharmacokinetics across a diverse set of antimicrobial and immunosuppressant drugs for which therapeutic drug monitoring is an important element of the standard of care. We believe the resulting orders of magnitude improvement in measuring these relationships is a critical step towards our long-range goal of rendering high-precision therapeutic drug monitoring convenient and cost effective.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $542,658 )
2025	2025	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	3/27/2025	NON-COMPETING CONTINUATION	$542,658
														Subtotal = $542,658

Issue Date FY: 2024 ( Subtotal = $595,697 )
2024	2024	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	5/9/2024	NON-COMPETING CONTINUATION	$595,697
														Subtotal = $595,697

Issue Date FY: 2023 ( Subtotal = $607,855 )
2023	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	3/23/2023	NON-COMPETING CONTINUATION	$607,855
2023	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	6	8/8/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	5/12/2023	COMPETING CONTINUATION	$45,540
2023	2020	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	5/12/2023	NON-COMPETING CONTINUATION	-$45,540
														Subtotal = $607,855

Issue Date FY: 2022 ( Subtotal = $637,408 )
2022	2022	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	5/23/2022	COMPETING CONTINUATION	$637,408
														Subtotal = $637,408

Issue Date FY: 2020 ( Subtotal = $541,961 )
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	7/23/2020	NON-COMPETING CONTINUATION	$541,961
														Subtotal = $541,961

Issue Date FY: 2019 ( Subtotal = $552,129 )
2019	2019	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	6/21/2019	NON-COMPETING CONTINUATION	$552,129
														Subtotal = $552,129

Issue Date FY: 2018 ( Subtotal = $558,056 )
2018	2018	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/22/2018	NON-COMPETING CONTINUATION	$558,056
														Subtotal = $558,056

Issue Date FY: 2017 ( Subtotal = $573,123 )
2017	2017	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/28/2017	NEW	$573,123
														Subtotal = $573,123

Grand Total All Awards = $4,608,887

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Bio-electrochemical detectors for in vivo continuous monitoring

Award Number: R01EB022015

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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