Monday, June 30, 2025 6/30/2025

Novel Computational Framework for Free-Breathing & Ungated Dynamic MRI

Award Number: R01EB019961
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2016
PERIOD OF PERFORMANCE END DATE: 07/31/2027

Group Awards By:

View Award Description

Novel Computational Framework for Free-Breathing & Ungated Dynamic MRI - Pulmonary hypertension (PH) is a chronic disease with high mortality. Several pulmonary vasodilators that reduce morbidity and mortality, especially with earlier initiation, have been FDA approved. However, the identification of individuals that would benefit from such therapies currently requires extensive testing of both the heart and the lungs using multiple modalities, resulting in high healthcare costs and delay in diagnosis. This proposal seeks to introduce an MR imaging imaging protocol to diagnose PH within a single imaging session by providing assessments of both cardiac and pulmonary systems. Current MRI methods have several limitations in the above setting. This renewal application aims to overcome these drawbacks using a novel generative SToRM (g-SToRM) framework, which capitalizes on the recent advances in deep generative models and unsupervised learning. This framework significantly improves the analysis manifold regularization framework (SToRM) for cardiac MRI, developed in the previous project. The proposed imaging methods will be validated by comparisons against current breath-held MRI and CT imaging protocols. The preliminary utility of the quantitative metrics to predict PH will also be determined.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	6	3/26/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$386,453
2025	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	3/26/2025	COMPETING CONTINUATION	-$386,453
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $548,956 )
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	6	8/27/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$548,956
2024	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	8/27/2024	COMPETING CONTINUATION	$0
														Subtotal = $548,956

Issue Date FY: 2023 ( Subtotal = $550,567 )
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	7/25/2023	COMPETING CONTINUATION	$550,567
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	9/26/2023	COMPETING CONTINUATION	$0
														Subtotal = $550,567

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	9/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $442,724 )
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	2/26/2019	NON-COMPETING CONTINUATION	$442,724
														Subtotal = $442,724

Issue Date FY: 2018 ( Subtotal = $833,273 )
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	3/30/2018	NON-COMPETING CONTINUATION	$47,927
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	8/29/2018	SUPPLEMENT FOR EXPANSION	$354,006
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	3/20/2018	NON-COMPETING CONTINUATION	$431,340
														Subtotal = $833,273

Issue Date FY: 2017 ( Subtotal = $635,400 )
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	5/25/2017	NON-COMPETING CONTINUATION	$48,919
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/14/2017	NON-COMPETING CONTINUATION	$440,281
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	2	9/21/2017	SUPPLEMENT FOR EXPANSION	$146,200
														Subtotal = $635,400

Issue Date FY: 2016 ( Subtotal = $466,527 )
2016	2016	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	2/5/2016	NEW	$466,527
														Subtotal = $466,527

Grand Total All Awards = $3,477,447

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Novel Computational Framework for Free-Breathing & Ungated Dynamic MRI

Award Number: R01EB019961

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2016

PERIOD OF PERFORMANCE END DATE: 07/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer