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Accelerating Community-Driven Medical Innovation with VTK

Award Number: R01EB014955
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2013
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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Accelerating Community-Driven Medical Innovation with VTK - Abstract Tens of thousands of medical researchers and practitioners around the world use VTK—the Visualization Toolkit—an open source, freely available software development toolkit providing advanced 3D interactive visualization, image processing and data analytics algorithms. They either use VTK directly in their in-house research applications or indirectly via one of the multitude of medical image analysis and bioinformatics applications that is built using VTK: 3D Slicer, Osirix, BioImageXD, MedINRIA, SCIRun, ParaView, and others. Furthermore, VTK also provides 3D visualizations for clinical applications such as BrainLAB’s VectorVision surgical guidance system and Zimmer’s prosthesis design and evaluation platform. VTK is currently accessed at a rate of more than 2.5 million/downloads per year, and remains a vital system even thirty years after its initial release in 1993. Considering its broad distribution and prevalent use, it can be argued that VTK has had a greater impact on medical research, and patient care, than any other open-source medical computing package. This proposal is in response to the multitude of requests we have been receiving from the VTK medical and biomedical computing communities. The aims of this work are as follows: Aim 1: Ubiquitous Visual Analytics: Establish an easy-to-use workflow so that users and developers can write VTK-based data analytics tools that are automatically transformed into portable, cross-platform executable modules. These modules–written just once–can then be used in a portable manner on any computing platform (desktop, cloud and web-based) and imported into applications. Aim 2: AI-Ready Visualization: Extend VTK’s current support of AR/VR to integrate AI into immersive workflows such as surgical and point-of-care applications. Provide visualization techniques, including saliency maps and Grad-CAM, to build trust in and validate AI workflows. Employ AI to drive the data transformation and rendering processes such as adaptively configuring transfer functions to highlight and efficiently convey clinically important information. Aim 3: Enhanced Community Support: Enable users and developers to more rapidly learn about, develop code for, and deliver VTK-based visual analytics applications. Using open-source LLM AI /ML models, train these models on the decades of community resources and millions of lines of VTK source code to provide rapid collation of relevant information, and enable the generation of programming extracts to accelerate the creation of specialized workflows.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,065,333 )
2025	2025	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	9	8/21/2025	COMPETING CONTINUATION	$133,167
2025	2025	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	9	12/20/2024	COMPETING CONTINUATION	$894,699
2025	2025	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	9	1/9/2025	COMPETING CONTINUATION	$37,467
														Subtotal = $1,065,333

Issue Date FY: 2024 ( Subtotal = -$4,779 )
2024	2022	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	9/5/2024	NON-COMPETING CONTINUATION	-$4,779
														Subtotal = -$4,779

Issue Date FY: 2022 ( Subtotal = $507,938 )
2022	2022	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	1/31/2022	NON-COMPETING CONTINUATION	$457,142
2022	2022	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	8	4/22/2022	NON-COMPETING CONTINUATION	$50,796
														Subtotal = $507,938

Issue Date FY: 2021 ( Subtotal = $498,914 )
2021	2021	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	5/28/2021	NON-COMPETING CONTINUATION	$0
2021	2021	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	3/23/2021	NON-COMPETING CONTINUATION	$498,914
														Subtotal = $498,914

Issue Date FY: 2020 ( Subtotal = $510,157 )
2020	2020	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	1/29/2020	NON-COMPETING CONTINUATION	$510,157
														Subtotal = $510,157

Issue Date FY: 2019 ( Subtotal = $511,729 )
2019	2019	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	4/9/2019	COMPETING CONTINUATION	$4,779
2019	2019	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	4/8/2019	COMPETING CONTINUATION	$508,446
2019	2016	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	4/9/2019	EXTENSION WITH OR WITHOUT FUNDS	-$1,496
														Subtotal = $511,729

Issue Date FY: 2018 ( Subtotal = -$3,284 )
2018	2016	KITWARE, INC.	28 CORPORATE DR	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	9/6/2018	EXTENSION WITH OR WITHOUT FUNDS	-$3,284
														Subtotal = -$3,284

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	KITWARE, INC.	28 CORPORATE DR	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	11/21/2016	EXTENSION WITH OR WITHOUT FUNDS	$186,253
2017	2015	KITWARE, INC.	28 CORPORATE DR	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	11/21/2016	NON-COMPETING CONTINUATION	-$186,253
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $602,833 )
2016	2016	KITWARE INC	28 CORPORATE DRIVE	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/5/2016	EXTENSION WITH OR WITHOUT FUNDS	$602,833
														Subtotal = $602,833

Issue Date FY: 2015 ( Subtotal = $604,548 )
2015	2015	KITWARE INC	28 CORPORATE DRIVE	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	4/30/2015	NON-COMPETING CONTINUATION	$604,548
														Subtotal = $604,548

Issue Date FY: 2014 ( Subtotal = $610,680 )
2014	2014	KITWARE INC	28 CORPORATE DRIVE	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	4/21/2014	NON-COMPETING CONTINUATION	$610,680
														Subtotal = $610,680

Issue Date FY: 2013 ( Subtotal = $644,139 )
2013	2013	KITWARE INC	28 CORPORATE DRIVE	CLIFTON PARK	NY	12065	SARATOGA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/15/2013	NEW	$644,139
														Subtotal = $644,139

Grand Total All Awards = $5,548,208

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Accelerating Community-Driven Medical Innovation with VTK

Award Number: R01EB014955

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2013

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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