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Multivariate methods for identifying multitask/multimodal brain imaging biomarkers

Award Number: R01EB006841
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Multivariate methods for identifying multitask/multimodal brain imaging biomarkers - Project Summary/Abstract The brain is extremely complex as we know, and involves a complicated interplay between functional infor- mation interacting with a structural (but not static) substrate. Brain imaging technology provides a way to sample various aspects of the brain albeit incompletely, providing a rich set of multitask and multimodal information. The field has advanced significantly in its approach to multimodal data, as there are more studies correlating, e.g. functional and structural measures. However, the vast majority of studies still ignore the joint information among two or more modalities or tasks. Such information is critical to consider as each brain imaging modality reports on a different aspect of the brain (e.g. gray matter integrity, blood flow changes, white matter integrity). The field is still striving to understand how to diagnose and treat complex mental illness, such as schizophrenia, bipolar disorder, depression, and others, and ignoring the joint information among tasks and modalities misses a critical, but available, part of the puzzle. Combining multimodal imaging data is not easy since, among other reasons, the combination of multiple data sets consisting of thousands of voxels or timepoints yields a very high dimen- sional problem, requiring appropriate data reduction strategies. In the previous phase of the project we devel- oped advanced approaches to capture high-dimensional relationships among 2 or more modalities. Our work continues to strongly support the benefits of multimodal data fusion to both provide a more complete picture of brain function and structure, but also to improve our ability to study and predict the impact of complex mental illness. In this new phase of the project, we will focus on methods that can fill some existing gaps, such as the ability to bridge spatial/temporal as well as structural/functional connectivity scales. We also propose a novel framework to integrate unimodal and multimodal features called chromatic fusion, which searches for combina- tions of multimodal `notes' which occupy a unique position in a latent (or dictionary) space. The proposed meth- ods will be validated using simulations, hybrid-data, and large N normative imaging data. Our proposed approach will be thoroughly tested using this large data set which includes multiple illnesses that have overlapping symp- toms and which can sometimes be misdiagnosed and treated with the wrong medications for months or years (schizophrenia, bipolar disorder, and unipolar depression). We will provide open source tools and release data throughout the duration of the project via GitHub and the NITRIC repository, hence enabling other investigators to compare their own methods with our own as well as to apply them to a large variety of brain disorders. 37


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	17	7/31/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $902,035 )
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	17	8/9/2023	NON-COMPETING CONTINUATION	$521,345
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	16	4/12/2023	SUPPLEMENT FOR EXPANSION	$380,690
														Subtotal = $902,035

Issue Date FY: 2022 ( Subtotal = $521,345 )
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	16	6/22/2022	NON-COMPETING CONTINUATION	$521,345
														Subtotal = $521,345

Issue Date FY: 2021 ( Subtotal = $1,104,919 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	15	9/14/2021	SUPPLEMENT FOR EXPANSION	$233,367
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	15	6/17/2021	NON-COMPETING CONTINUATION	$510,918
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	President's Council on Fitness, Sports, and Nutrition	002	14	5/28/2021	SUPPLEMENT FOR EXPANSION	$360,634
2021	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	14	5/7/2021	COMPETING CONTINUATION	$216,425
2021	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	13	5/7/2021	NON-COMPETING CONTINUATION	-$216,425
														Subtotal = $1,104,919

Issue Date FY: 2020 ( Subtotal = $542,808 )
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	009	14	7/30/2020	COMPETING CONTINUATION	$542,808
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	008	13	3/31/2020	NON-COMPETING CONTINUATION	$364,095
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	005	13	1/14/2020	NON-COMPETING CONTINUATION	-$364,095
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	13	1/14/2020	NON-COMPETING CONTINUATION	$364,095
2020	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	10	1/14/2020	SUPPLEMENT FOR EXPANSION	-$162,344
2020	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	10	1/14/2020	NON-COMPETING CONTINUATION	$201,751
2020	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	007	10	3/31/2020	SUPPLEMENT FOR EXPANSION	-$162,344
2020	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	10	1/14/2020	NON-COMPETING CONTINUATION	-$201,751
2020	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	10	1/14/2020	SUPPLEMENT FOR EXPANSION	$162,344
2020	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	006	10	3/31/2020	NON-COMPETING CONTINUATION	-$201,751
														Subtotal = $542,808

Issue Date FY: 2019 ( Subtotal = $400,000 )
2019	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	13	8/6/2019	NON-COMPETING CONTINUATION	$400,000
2019	2018	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	12	1/14/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$400,000
2019	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	11	1/14/2019	NON-COMPETING CONTINUATION	-$400,000
														Subtotal = $400,000

Issue Date FY: 2018 ( Subtotal = $400,000 )
2018	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	11	9/5/2018	NON-COMPETING CONTINUATION	$400,000
														Subtotal = $400,000

Issue Date FY: 2017 ( Subtotal = $562,344 )
2017	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	005	10	8/17/2017	NON-COMPETING CONTINUATION	$400,000
2017	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	006	10	9/14/2017	SUPPLEMENT FOR EXPANSION	$162,344
2017	2016	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	9	5/3/2017	COMPETING CONTINUATION	-$269,777
2017	2016	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	9	2/6/2017	COMPETING CONTINUATION	$802,799
2017	2014	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	8	2/6/2017	NON-COMPETING CONTINUATION	-$519,454
2017	2013	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	7	5/3/2017	NON-COMPETING CONTINUATION	$269,777
2017	2013	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	2/6/2017	NON-COMPETING CONTINUATION	-$283,345
														Subtotal = $562,344

Issue Date FY: 2016 ( Subtotal = $400,000 )
2016	2016	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	9	8/15/2016	COMPETING CONTINUATION	$400,000
2016	2014	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	8	8/15/2016	NON-COMPETING CONTINUATION	$0
2016	2014	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	7/8/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $400,000

Issue Date FY: 2014 ( Subtotal = $519,454 )
2014	2014	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	6/26/2014	NON-COMPETING CONTINUATION	$519,454
														Subtotal = $519,454

Issue Date FY: 2013 ( Subtotal = $513,792 )
2013	2013	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	6/21/2013	NON-COMPETING CONTINUATION	$513,792
2013	2013	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	9/6/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $513,792

Issue Date FY: 2012 ( Subtotal = $535,219 )
2012	2012	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	6/18/2012	NON-COMPETING CONTINUATION	$535,219
														Subtotal = $535,219

Issue Date FY: 2011 ( Subtotal = $548,402 ) (Continued on the next page)
Grand Total All Awards = $8,512,023

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Multivariate methods for identifying multitask/multimodal brain imaging biomarkers

Award Number: R01EB006841

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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