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Probes and Methods for Clinical Oximetry

Award Number: R01EB004031
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2004
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Probes and Methods for Clinical Oximetry - PROJECT SUMMARY EPR oximetry has been established in preclinical models to be a very reliable method for the direct and repeated measurement of tissue oxygen levels. Ongoing clinical studies in cancer patients have confirmed that EPR oximetry can be extended to human subjects very effectively, thus addressing a critical, but unmet, need—the ability to make repeated measurements of tissue oxygen concentration in the clinic. These studies have also revealed the potential shortcomings of the technology and informed further developments that are needed to achieve the full clinical potential of EPR oximetry for cancer therapy. The current EPR scanners are based on the traditional CW (continuous wave, frequency-domain) mode of operation using magnetic-field seep and modulation, both of which are necessary for measuring paramagnetic probes with much shorter relaxation times (typically on the order of nanoseconds), for which a pulse (time-domain) mode of operation is prohibitively difficult. The CW EPR oximetry requires stringent magnetic field homogeneity, longer data acquisition time, motion-induced artifacts in the data, and, more importantly, a cumbersome operation. On the other hand, pulse EPR technology, which uses spin echo-based relaxation-time measurements for oximetry, is a simple and straightforward approach that is more efficient, faster, and less dependent on field homogeneity and object motions. This proposal will combine pulse technology with a suite of oxygen-sensing probes (OxyChip and related materials) developed as part of the PI’s current NIH funding program to develop an advanced pulse EPR scanner, as well as procedures for the scanner’s use in human subjects in a clinical setting. We propose the following specific aims to achieve the overall objective of developing an advanced pulse EPR scanner for the repeated measurement of oxygen concentration in human subjects: (1) Development of a multi-modal EPR scanner for clinical oximetry and imaging. (2) Validation of the multi-modal pulse EPR scanner for repeated measurements of oxygen concentration using tissue phantoms and animal models of tumor. (3) Clinical evaluation of the pulse EPR scanner, for the measurement of oxygen concentration in healthy and cancer patients. The availability of this capability would be a new addition to clinical medicine that would immediately and significantly enhance the treatment of various disease states and malignancies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2021	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	13	12/16/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	13	8/29/2024	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,298,185 )
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	13	7/27/2021	COMPETING CONTINUATION	$2,298,187
2021	2018	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	12	5/29/2021	SUPPLEMENT FOR EXPANSION	-$2
														Subtotal = $2,298,185

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	12	2/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	12	3/28/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $162,463 )
2018	2018	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	12	9/9/2018	SUPPLEMENT FOR EXPANSION	$162,463
2018	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	12	3/21/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $162,463

Issue Date FY: 2017 ( Subtotal = $522,063 )
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	12	8/16/2017	NON-COMPETING CONTINUATION	$0
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	12	5/26/2017	NON-COMPETING CONTINUATION	$50,407
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	12	8/16/2017	SUPPLEMENT FOR EXPANSION	$18,000
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	12	2/22/2017	NON-COMPETING CONTINUATION	$453,656
														Subtotal = $522,063

Issue Date FY: 2016 ( Subtotal = $508,145 )
2016	2016	DARTMOUTH COLLEGE	11 ROPE FERRY ROAD, #6210	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	11	2/4/2016	NON-COMPETING CONTINUATION	$508,145
														Subtotal = $508,145

Issue Date FY: 2015 ( Subtotal = $477,692 )
2015	2015	DARTMOUTH COLLEGE	11 ROPE FERRY ROAD, #6210	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	10	9/23/2015	NON-COMPETING CONTINUATION	$0
2015	2015	DARTMOUTH COLLEGE	11 ROPE FERRY ROAD, #6210	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	10	2/27/2015	NON-COMPETING CONTINUATION	$477,692
														Subtotal = $477,692

Issue Date FY: 2014 ( Subtotal = $509,166 )
2014	2014	DARTMOUTH COLLEGE	11 ROPE FERRY ROAD, #6210	HANOVER	NH	03755	GRAFTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	9	2/27/2014	COMPETING CONTINUATION	$509,166
														Subtotal = $509,166

Issue Date FY: 2011 ( Subtotal = $321,161 )
2011	2011	OHIO STATE UNIVERSITY	1800 CANNON DR/700 LINCOLN TOW	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	7/14/2011	NON-COMPETING CONTINUATION	$321,161
														Subtotal = $321,161

Issue Date FY: 2010 ( Subtotal = $334,125 )
2010	2010	OHIO STATE UNIVERSITY	1800 CANNON DR/700 LINCOLN TOW	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	7/14/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$334,125
2010	2009	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	6	7/14/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $334,125

Issue Date FY: 2009 ( Subtotal = $337,500 )
2009	2009	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	6	7/20/2009	NON-COMPETING CONTINUATION	$337,500
2009	2007	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	11/19/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $337,500

Issue Date FY: 2008 ( Subtotal = $337,500 )
2008	2008	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	9/22/2008	COMPETING CONTINUATION	$337,500
														Subtotal = $337,500

Issue Date FY: 2007 ( Subtotal = $318,945 )
2007	2007	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/6/2007	NON-COMPETING CONTINUATION	$318,945
														Subtotal = $318,945

Issue Date FY: 2006 ( Subtotal = $328,471 )
2006	2006	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	4/10/2006	NON-COMPETING CONTINUATION	$328,471
														Subtotal = $328,471

Issue Date FY: 2005 ( Subtotal = $336,375 )
2005	2005	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	4/22/2005	NON-COMPETING CONTINUATION	$336,375
														Subtotal = $336,375

Issue Date FY: 2004 ( Subtotal = $336,375 )
2004	2004	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/28/2004	NEW	$336,375
														Subtotal = $336,375

Grand Total All Awards = $7,128,166

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Probes and Methods for Clinical Oximetry

Award Number: R01EB004031

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2004

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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