Sunday, May 11, 2025 5/11/2025

Designing Novel MR Imaging Tools to Quantify Lower-Limb Exercise Adaptations in Knee Osteoarthritis

Award Number: R01EB002524
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Designing Novel MR Imaging Tools to Quantify Lower-Limb Exercise Adaptations in Knee Osteoarthritis - PROJECT SUMMARY Knee osteoarthritis (OA) is a major cause of disability without a cure that affects 20+ million US adults and leads to large financial burdens. While the etiology of OA is unknown, it is thought to be related to altered biochemical or biomechanical function of the joint. OA is slow to develop; the current treatment strategies for OA are pain control using lifestyle or therapeutic interventions, until the patient requires a total knee replacement. The progressive loss of periarticular muscle mass and function reduces joint stability and health. Loss of muscle mass and function is associated with aging, as is OA development and progression. While many OA studies examine the bone, cartilage, synovium, and meniscus in the knee, the interplay between muscle function and structure, and the initiation and progression of OA is unclear, despite recommendations of exercise as a conservative treatment. In this study, we seek to build new imaging tools to sensitively measure the effects of muscle strength, quality, and function on OA initiation and progression. This is an appealing area to study because disease- modifying treatments such as exercise, physical therapy, and muscle-building drugs could both manage pain and change disease progression. Toward this goal, we will build imaging tools to provide unparalleled insights into exercise-induced microstructural changes in the muscle, subtle compositional changes in OA, and biomechanically inspired biomarkers of how joint loads affect cartilage pressure. In Aim 1, we will build and validate a multi-vendor, highly accelerated, multi-parametric whole-bilateral- limb magnetic resonance imaging (MRI) protocol that will enable acquiring high-resolution quantitative imaging of both knees, thighs, and calves in under 20 minutes of scan time. In Aim 2, we will compute fully automated and novel biomechanics-inspired imaging biomarkers for the cartilage, bone, and muscle. These will include cartilage pressure maps to assess spatial joint loading profile, as well as neural shape models to model the complex shapes of bones and muscles. In Aim 3, we will assess the responsiveness of these imaging measures in a two-year longitudinal study in patients with early OA undergoing a walking-based muscle strengthening intervention. We will quantify the impact of exercise on muscle structure, tissues in the knee, pain relief and OA progression. We hypothesize that our novel imaging biomarkers have stronger association than current functional tests on pain relief and OA progression, and that our baseline imaging can predict subject-specific pain relief. Overall, our novel tools will elucidate the mechanistic interplay between exercise and OA physiology, towards developing precision muscle strengthening programs. These insights will help accelerate the elusive quest towards developing disease-modifying strategies for OA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $573,045 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	19	4/10/2025	NON-COMPETING CONTINUATION	$573,045
2025	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	18	3/26/2025	COMPETING CONTINUATION	$237,978
2025	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	17	3/26/2025	NON-COMPETING CONTINUATION	-$237,978
														Subtotal = $573,045

Issue Date FY: 2024 ( Subtotal = $587,432 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	18	8/1/2024	COMPETING CONTINUATION	$587,432
2024	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	17	8/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $587,432

Issue Date FY: 2023 ( Subtotal = $604,062 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	17	3/30/2023	NON-COMPETING CONTINUATION	$604,062
														Subtotal = $604,062

Issue Date FY: 2022 ( Subtotal = $621,368 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	16	4/22/2022	NON-COMPETING CONTINUATION	$62,139
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	16	3/22/2022	NON-COMPETING CONTINUATION	$559,229
														Subtotal = $621,368

Issue Date FY: 2021 ( Subtotal = $611,185 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	15	5/28/2021	NON-COMPETING CONTINUATION	$0
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	15	3/25/2021	NON-COMPETING CONTINUATION	$611,185
2021	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	14	3/17/2021	COMPETING CONTINUATION	$62,125
2021	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	13	3/17/2021	SUPPLEMENT FOR EXPANSION	-$62,125
														Subtotal = $611,185

Issue Date FY: 2020 ( Subtotal = $612,595 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	14	6/12/2020	COMPETING CONTINUATION	$612,595
2020	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	13	6/12/2020	NON-COMPETING CONTINUATION	$0
2020	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	13	3/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $612,595

Issue Date FY: 2018 ( Subtotal = $676,784 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	13	9/21/2018	SUPPLEMENT FOR EXPANSION	$156,275
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	13	4/2/2018	NON-COMPETING CONTINUATION	$52,051
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	13	2/23/2018	NON-COMPETING CONTINUATION	$468,458
														Subtotal = $676,784

Issue Date FY: 2017 ( Subtotal = $533,510 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	12	1/19/2017	NON-COMPETING CONTINUATION	$480,158
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	12	5/31/2017	NON-COMPETING CONTINUATION	$53,352
														Subtotal = $533,510

Issue Date FY: 2016 ( Subtotal = $532,065 )
2016	2016	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	11	1/27/2016	NON-COMPETING CONTINUATION	$532,065
														Subtotal = $532,065

Issue Date FY: 2015 ( Subtotal = $534,190 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	10	3/9/2015	COMPETING CONTINUATION	$534,190
														Subtotal = $534,190

Issue Date FY: 2013 ( Subtotal = $438,452 )
2013	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	9	3/15/2013	NON-COMPETING CONTINUATION	$418,459
2013	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	9	7/19/2013	NON-COMPETING CONTINUATION	$19,993
														Subtotal = $438,452

Issue Date FY: 2012 ( Subtotal = $502,243 )
2012	2012	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	3/6/2012	NON-COMPETING CONTINUATION	$502,243
														Subtotal = $502,243

Issue Date FY: 2011 ( Subtotal = $479,254 )
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	5/24/2011	NON-COMPETING CONTINUATION	$30,513
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	3/22/2011	NON-COMPETING CONTINUATION	$448,741
														Subtotal = $479,254

Issue Date FY: 2010 ( Subtotal = $504,276 )
2010	2010	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	6	5/27/2010	COMPETING CONTINUATION	$504,276
2010	2007	STANFORD UNIVERSITY	616 SERRA STREET	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	5/27/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $504,276

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2007	STANFORD UNIVERSITY	616 SERRA STREET	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	9/29/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $336,090 )
2007	2007	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	7/6/2007	NON-COMPETING CONTINUATION	$336,090
														Subtotal = $336,090

Issue Date FY: 2006 ( Subtotal = $345,235 )
2006	2006	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/19/2006	NON-COMPETING CONTINUATION	$345,235
														Subtotal = $345,235

Issue Date FY: 2005 ( Subtotal = $352,654 ) (Continued on the next page)
Grand Total All Awards = $9,541,787

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Designing Novel MR Imaging Tools to Quantify Lower-Limb Exercise Adaptations in Knee Osteoarthritis

Award Number: R01EB002524

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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