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NANOSENSING AND ACTUATION USING CELL MIMETICS

Award Number: R01EB000657
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2002
PERIOD OF PERFORMANCE END DATE: 04/30/2011

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NANOSENSING AND ACTUATION USING CELL MIMETICS - DESCRIPTION (provided by applicant): The central premise of this proposal is that effective biomedical sensors must interface with biological systems at the molecular scale. These devices must extract and process information from a complex environment of interacting non-linear biomolecular processes and, in an ideal embodiment, intervene in processes gone awry. Functionality at this level of complexity dictates the requirements of engineering functional nanoscale components within microscale structures, facilitating highly complex processing schemes that can be implemented in very small volumes. Nature's answer to this design challenge is the cell. The objective of this work is to develop sensors that mimic the dimensions and some portion of the functionality of a cell. By mimicking cellular features, effective operation and interfacing to biological systems be achieved. To realize this ideal, we will exploit advances in nanofabrication that allow for the synthesis of physical features on length scales ranging from nanometers to centimeters. Carbon nanofiber- based membranes, will be arranged to create small volume containers. The nanoscale features of these membranes will be engineered to control chemically specific transport that influences enzyme-based reaction systems assembled within these containers. The resulting cell mimic structures will allow for physically and chemically specific sensing and for implementation of complex, engineered biochemical networks in contained volumes and under concentration conditions that closely model those of natural cells.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $403,328 )
2010	2010	UT-BATTELLE, LLC	P.O. BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	4/13/2010	NON-COMPETING CONTINUATION	$403,328
														Subtotal = $403,328

Issue Date FY: 2009 ( Subtotal = $405,019 )
2009	2009	UT-BATTELLE, LLC	P.O. BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	4/8/2009	NON-COMPETING CONTINUATION	$405,019
														Subtotal = $405,019

Issue Date FY: 2008 ( Subtotal = $402,478 )
2008	2008	UT-BATTELLE, LLC	POST OFFICE BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	3/13/2008	NON-COMPETING CONTINUATION	$402,478
														Subtotal = $402,478

Issue Date FY: 2007 ( Subtotal = $406,427 )
2007	2007	UT-BATTELLE, LLC	POST OFFICE BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	4/24/2007	COMPETING CONTINUATION	$406,427
														Subtotal = $406,427

Issue Date FY: 2005 ( Subtotal = $407,543 )
2005	2005	UT-BATTELLE, LLC	POST OFFICE BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	5/19/2005	NON-COMPETING CONTINUATION	$407,543
														Subtotal = $407,543

Issue Date FY: 2004 ( Subtotal = $409,744 )
2004	2004	UT-BATTELLE, LLC	POST OFFICE BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/25/2004	NON-COMPETING CONTINUATION	$409,744
														Subtotal = $409,744

Issue Date FY: 2003 ( Subtotal = $486,341 )
2003	2003	UT-BATTELLE, LLC	POST OFFICE BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	9/11/2003	SUPPLEMENT FOR EXPANSION	$73,590
2003	2003	UT-BATTELLE, LLC	POST OFFICE BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/23/2003	NON-COMPETING CONTINUATION	$412,751
														Subtotal = $486,341

Issue Date FY: 2002 ( Subtotal = $414,077 )
2002	2002	UT-BATTELLE, LLC	POST OFFICE BOX 2008	OAK RIDGE	TN	37831	ANDERSON	USA	Grants for Training in Emergency Medical Services	000	1	9/25/2002	NEW	$414,077
														Subtotal = $414,077

Grand Total All Awards = $3,334,957

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NANOSENSING AND ACTUATION USING CELL MIMETICS

Award Number: R01EB000657

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2002

PERIOD OF PERFORMANCE END DATE: 04/30/2011

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