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INTEGRATED BAYESIAN ANALYSIS OF MEG AND FMRI

Award Number: R01EB000310
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 07/01/1999
PERIOD OF PERFORMANCE END DATE: 06/30/2007

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INTEGRATED BAYESIAN ANALYSIS OF MEG AND FMRI - The goal of this proposal is to develop an integrated probabilistic approach to functional brain imaging using electromagnetic and hemodynamic techniques that capitalizes upon the strengths and minimizes the weaknesses of each technique alone. The fundamental rationale for attempting to integrate electromagnetic and hemodynamic imaging techniques is: (1) no single technique provides the spatial and temporal resolution needed for clinical and research applications; and (2) hemodynamic and electromagnetic techniques have complementary strengths and weaknesses that can be exploited in an integrated analysis. The mathematical basis for our probabalistic approach is Bayesian Inference. In contrast to most existing approaches to analysis of functional imaging data the results of our Bayesian inferential approach is not a single "best" estimate of brain activity according to some criterion, but rather estimates of the full probability distribution for parameters of interest. Furthermore, Bayesian inference can incorporate uncertain models, such as those of the hemodynamic response in fMRI or of the EEG forward model, which depends on uncertain conductivity profiles. We believe this Bayesian inference approach could significantly improve our ability to gain robust spatial-temporal information on neural activation from existing functional neural imaging modalities. In order to realize this we propose to, 1) develop a fully integrated analysis of fMRI and MEG data, 2) develop a probabilistic EEG foward model so that our MEG analysis can be used for EEG data, and 3) distribute, optimize, test and refine the spatial-temporal MEG analysis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $585,015 )
2006	2006	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	9	8/31/2006	NON-COMPETING CONTINUATION	$585,015
														Subtotal = $585,015

Issue Date FY: 2005 ( Subtotal = $469,468 )
2005	2005	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	6/16/2005	NON-COMPETING CONTINUATION	$469,468
														Subtotal = $469,468

Issue Date FY: 2004 ( Subtotal = $451,742 )
2004	2004	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	6/15/2004	NON-COMPETING CONTINUATION	$451,742
														Subtotal = $451,742

Issue Date FY: 2003 ( Subtotal = $442,777 )
2003	2003	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	7/18/2003	COMPETING CONTINUATION	$442,777
														Subtotal = $442,777

Issue Date FY: 2002 ( Subtotal = $377,815 )
2002	2002	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/3/2002	OTHER REVISION	$377,815
														Subtotal = $377,815

Grand Total All Awards = $2,326,817

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INTEGRATED BAYESIAN ANALYSIS OF MEG AND FMRI

Award Number: R01EB000310

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 07/01/1999

PERIOD OF PERFORMANCE END DATE: 06/30/2007

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