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Population-based Incidence, Time Trends, and Early Life Factors Associated with Type 2 Diabetes Among Asian American, Native Hawaiian, and Pacific Islander Adolescents and Young Adults

Award Number: R01DK139116
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/28/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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Population-based Incidence, Time Trends, and Early Life Factors Associated with Type 2 Diabetes Among Asian American, Native Hawaiian, and Pacific Islander Adolescents and Young Adults - The number of adolescents and young adults (AYA) with type 2 diabetes (T2D) has risen sharply in parallel with the obesity epidemic in the U.S. If current trends continue, the number of T2D cases among American youth is projected to increase more than seven-fold by 2060. Youth-onset T2D is debilitating, typically with a more aggressive clinical presentation compared with adult-onset T2D. AYA of Asian American (AsA) and Pacific Islander (PI) descent are experiencing the steepest yearly increase in T2D incidence. Unfortunately, current epidemiologic and etiologic studies of AYA T2D are extremely limited due to a lack of population-based studies with sufficiently large samples, and almost no data on T2D in AsA and PI youth. Despite their rapidly growing population, little is known about the risk factors among AsA and PI individuals because they have not been well studied; when they are included in research, these subpopulations are very often aggregated into a single group, masking important health differences. Our long-term goal is to better understand the epidemiology of T2D among AYA, with a special focus on AsA and PI, identifying high-risk subpopulations and modifiable risk factors to inform early detection and design upstream intervention strategies to improve the health of all AYA. To fill extant knowledge gaps and inform future guidelines and prevention strategies, we will conduct a large longitudinal cohort study of over 5 million AYA members at Kaiser Permanente Northern California and Kaiser Permanente Southern California, integrated healthcare organizations with memberships representative of the source population. All members ages 10 to 30 identified from 2007 to the present will be included. We will use electronic health record data to link diagnosis, laboratory, and other demographic and clinical data to describe incidence and temporal trends of youth-onset T2D among AsA and PI AYA (Aim 1). We will then investigate early life (e.g., gestational diabetes) and childhood risk factors associated with youth-onset T2D, and examine differences across relevant subgroups (Aim 2). This study will advance our understanding of the epidemiology and etiology of youth-onset T2D in AsA and PI subpopulations and provide evidence needed to inform future prevention tools to improve the health of American AYA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $706,898 )
2026	2026	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/28/2026	NON-COMPETING CONTINUATION	$706,898
														Subtotal = $706,898

Issue Date FY: 2025 ( Subtotal = $711,791 )
2025	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	1/27/2025	NEW	$711,791
														Subtotal = $711,791

Grand Total All Awards = $1,418,689

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Population-based Incidence, Time Trends, and Early Life Factors Associated with Type 2 Diabetes Among Asian American, Native Hawaiian, and Pacific Islander Adolescents and Young Adults

Award Number: R01DK139116

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/28/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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