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Beyond Urea Kinetics: Balancing Tradeoffs in Dialyzer Design for the Next 50 Years

Award Number: R01DK139048
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/16/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Beyond Urea Kinetics: Balancing Tradeoffs in Dialyzer Design for the Next 50 Years - The 548,000 Americans who rely on dialysis to stave off death from kidney failure suffer from malnutrition, inflammation, immune defects, and vastly increased incidence of coronary thromboses and pulmonary embolisms. Conventional hemodialysis cartridges are designed to remove urea, because urea removal is fundamental to dialysis quality metrics. However, urea is a largely non-toxic stand-in for other waste products, and urea-focused efforts fail to capture the complexity of dialysis in renal failure. One class of uremic wastes that are thought to contribute to the illness of dialysis patients is called protein-bound uremic toxins (PBUTs), such as indoxyl sulfate, kynurenic acid, and p- cresyl. Because dialyzers do not allow albumin to pass from blood to dialysate, the toxins bound to albumin do not pass in appreciable quantities either. Dialyzer design has focused on urea removal. We hypothesize that increasing the residence time of blood in the dialyzer will allow for increased PBUT removal and eventually, better health for patients who depend on dialysis. Hemodialysis treatment is associated with an increased risk of clotting despite anemia, uremia, and chronic heparin use. The superphysiological shear stresses that platelets experience in hemodialysis appear to prime them to form clots inappropriately. We designed a parallel-plate dialyzer with tightly controlled shear forces. We will test whether platelet activation with this novel design reduces platelet activation, compared to conventional dialyzers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $482,146 )
2026	2026	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	8/10/2026	NON-COMPETING CONTINUATION	$482,146
2026	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/24/2026	NON-COMPETING CONTINUATION	$0
2026	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	7/15/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $482,146

Issue Date FY: 2025 ( Subtotal = $479,880 )
2025	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	8/13/2025	NON-COMPETING CONTINUATION	$479,880
														Subtotal = $479,880

Issue Date FY: 2024 ( Subtotal = $518,661 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/16/2024	NEW	$518,661
														Subtotal = $518,661

Grand Total All Awards = $1,480,687

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Beyond Urea Kinetics: Balancing Tradeoffs in Dialyzer Design for the Next 50 Years

Award Number: R01DK139048

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/16/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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