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Systematic validation of biomarkers predictive of IA and T1D and their relationship with disease development

Award Number: R01DK138335
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/17/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Systematic validation of biomarkers predictive of IA and T1D and their relationship with disease development - Summary: Type 1 diabetes (T1D) is a metabolic disease currently without a cure that results in destruction of insulin- producing β cells of the pancreas via an autoimmune response. T1D treatment requires insulin administration and greatly reduces life quality and expectancy. Development and persistence of islet autoimmunity (IA) can be determined by circulating autoantibodies against islet proteins. However, novel biomarkers are needed to: 1) better understand the mechanisms that trigger and drive IA; and 2) predict individual progression through the stages of the disease. To identify new biomarkers, we have recently completed a plasma proteomics analysis for The Environmental Determinants of Diabetes in the Young (TEDDY). This nested case-control study 1 (NCC1) included 401 children who developed IA (at median age of 21 months) and 94 children who progressed to clinical T1D (at median age of 29 months), matched against controls. We identified 376 proteins as candidate biomarkers; 83 of these proteins were validated as significant predictors of either IA or progression to T1D in longitudinal analyses of 6,426 samples. We also identified panels of proteins that can predict, with high accuracy, development of islet autoimmunity (AUC=0.918) and progression to T1D (AUC=0.871) 6 months prior to seroconversion by machine learning analysis. Limitations of the TEDDY NCC1 included limited follow-up and very young age (≤6 years) of the participants. IA and progression to T1D can occur over a much broader age range, and the cellular and systemic processes involved may differ in younger vs older children. In the next case control study 2 (NCC2), TEDDY monitored individuals until 15 years of age, an additional 501 participants developed IA (at median age of 89 months) and an additional 345 progressed to T1D (at median age of 108 months). Here we propose to perform a longitudinal analysis of the NCC2 samples with a highly multiplexed, sensitive, and robust targeted proteomics analysis to simultaneously validate biomarkers identified in the NCC1 and to provide information about the biological processes regulated during disease development. More specifically, we propose the following specific aims: (I) validate predictive biomarkers of islet autoimmunity; (II) validate predictive biomarkers of progression to T1D; and (III) determine mechanisms underlying development of IA and progression to T1D. To fulfill these aims we will perform a large-scale targeted proteomics analysis of 8 time points from 48 months pre-seroconversion to 12 months post-seroconversion of individuals that only developed islet autoimmunity and individuals that developed clinical diabetes, paired with controls, totaling 6,400 samples. The results of this project should bring the field one step closer to developing clinical biomarkers and associated assays that can predict all phases of T1D development in addition to identifying possible causes. This knowledge gained will likely open opportunities to develop preventive interventions against T1D.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $482,550 )
2026	2026	BATTELLE MEMORIAL INSTITUTE	902 BATTELLE BLVD	RICHLAND	WA	99354	BENTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	12/17/2025	NON-COMPETING CONTINUATION	$482,550
														Subtotal = $482,550

Issue Date FY: 2025 ( Subtotal = $691,441 )
2025	2025	BATTELLE MEMORIAL INSTITUTE	902 BATTELLE BLVD	RICHLAND	WA	99354	BENTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	2/19/2025	NON-COMPETING CONTINUATION	$0
2025	2025	BATTELLE MEMORIAL INSTITUTE	902 BATTELLE BLVD	RICHLAND	WA	99354	BENTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/17/2025	NON-COMPETING CONTINUATION	$691,441
														Subtotal = $691,441

Issue Date FY: 2024 ( Subtotal = $730,660 )
2024	2024	BATTELLE MEMORIAL INSTITUTE	902 BATTELLE BLVD	RICHLAND	WA	99354	BENTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	1/17/2024	NEW	$730,660
														Subtotal = $730,660

Grand Total All Awards = $1,904,651

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Systematic validation of biomarkers predictive of IA and T1D and their relationship with disease development

Award Number: R01DK138335

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/17/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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