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Applying a life course approach to assess the impact of psychosocial stress on allostatic load

Award Number: R01DK137805
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2027

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Applying a life course approach to assess the impact of psychosocial stress on allostatic load - Allostatic load, characterized by dysregulation across multiple physiological systems, has been linked to increased risk of chronic diseases such as diabetes, heart disease, and stroke. However, the prevalence of allostatic load varies across segments of the US population, with some groups experiencing a higher burden, particularly during middle and older adulthood. The reasons for these differences are not fully understood, despite research into contributing factors such as diet and socioeconomic conditions. Psychosocial stress has emerged as a key risk factor for allostatic load. While it is understood to operate across multiple contexts—such as interpersonal interactions and neighborhood environments—the combined influence of multiple forms of psychosocial stress on physiological dysregulation remains understudied, as do the biological mechanisms that link these experiences to elevated allostatic load. This study aims to clarify the relationship between multiple forms of psychosocial stress and allostatic load using data from three large, nationally representative cohort studies, in order to inform more effective strategies to reduce physiological wear and tear over the life course. By assessing the associations between interpersonal and neighborhood-level psychosocial stress and allostatic load, the study will quantify how these stressors contribute to physiological burden. The study will also investigate whether the “Conserved Transcriptional Response to Adversity” (CTRA) gene expression profile mediates the relationship between psychosocial stress and allostatic load, and evaluate whether social integration buffers these associations. Overall, this study has the potential to inform the optimization of clinical and place-based interventions aimed at reducing allostatic load by identifying when, where, and for whom such efforts may be most effective.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $403,287 )
2026	2026	NEW YORK UNIVERSITY	70 WASHINGTON SQ S FL 11	NEW YORK	NY	10012	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	12/22/2025	NON-COMPETING CONTINUATION	$403,287
														Subtotal = $403,287

Issue Date FY: 2025 ( Subtotal = $410,060 )
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	11/13/2024	NON-COMPETING CONTINUATION	$369,056
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	7/24/2025	NON-COMPETING CONTINUATION	$41,004
														Subtotal = $410,060

Issue Date FY: 2024 ( Subtotal = $427,927 )
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	1/15/2024	NEW	$427,927
														Subtotal = $427,927

Grand Total All Awards = $1,241,274

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Applying a life course approach to assess the impact of psychosocial stress on allostatic load

Award Number: R01DK137805

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2027

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