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Control Systems Engineering to Address the Problem of Weight Loss Maintenance: A System Identification Experiment to Model Behavioral & Psychosocial Factors Measured by Ecological Momentary Assessment

Award Number: R01DK137423
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Control Systems Engineering to Address the Problem of Weight Loss Maintenance: A System Identification Experiment to Model Behavioral & Psychosocial Factors Measured by Ecological Momentary Assessment - PROJECT SUMMARY/ABSTRACT The most major and critical barrier to the treatment of obesity and comorbid conditions is weight loss maintenance. A range of established treatments reliably produce clinically significant initial weight losses of 3- 30% of body weight, which substantially reduce risk and severity of disease, even when the weight loss is modest. However, weight loss maintenance is uniformly poor, with most patients regaining at least some weight and behaviorally treated patients returning to baseline weight within 5 years, thereby renewing risk for weight-related illness. While regain is common, it is difficult to predict when or why an individual will begin to regain lost weight. We therefore propose an experiment that will enable a future just-in-time adaptive intervention (JITAI) that passively monitors triggers for lapse, identifies which triggers are most likely to contribute to lapse for each patient, accurately predicts when a patient is entering a period of heightened risk for lapse, determines the type(s) of intervention(s) that are likely to prevent the lapse, administers intervention for as long as needed to reestablish healthy behavioral patterns for weight maintenance, and then returns to passive monitoring. This automated intervention is nearly within reach via a combination of mobile technologies, analytics, and behavioral intervention techniques that our team has already established, including: (a) an Ecological Momentary Assessment platform to measure daily weight and related behavioral and psychosocial influences; (b) an analytic framework, Control Systems Engineering, capable of modeling complex patterns of behavioral and psychosocial influences on weight, and determining how best to intervene on this “system” to facilitate weight loss maintenance; and (c) a toolbox of empirically validated behavioral intervention strategies known to be effective for addressing common causes of weight regain. This proposal aims to support our multidisciplinary team in combining our areas of expertise and prior work to enable a “system identification (ID) experiment” with N=120 participants who have recently lost ≥3% of initial body weight in a 6-month behavioral obesity treatment (N=180 will undergo behavioral obesity treatment to produce this sample), who will be studied over a 12-month maintenance period. The data will be used to validate and refine a theoretical model of weight loss maintenance. During the study, 4 interventions from the behavioral toolbox will be administered randomly, thus providing necessary data on: (a) how lapse triggers are related to each other and weight, and (b) which interventions are effective for addressing which triggers, for whom, and under what circumstances. The end result of this project will be a control systems algorithm that can predict when, for whom, and how to intervene to prevent weight regain, and a mobile platform that can be used to deliver JITAI in the next phase of research. This highly innovative approach to weight loss maintenance could ultimately prevent regain in large numbers of individuals at low cost using smartphone technology that is already ubiquitous.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $614,139 )
2025	2025	THE MIRIAM HOSPITAL	164 SUMMIT AVE	PROVIDENCE	RI	02906	PROVIDENCE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	8/7/2025	NON-COMPETING CONTINUATION	$614,139
														Subtotal = $614,139

Issue Date FY: 2024 ( Subtotal = $598,366 )
2024	2024	THE MIRIAM HOSPITAL	164 SUMMIT AVE	PROVIDENCE	RI	02906	PROVIDENCE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	7/19/2024	NON-COMPETING CONTINUATION	$598,366
2024	2023	THE MIRIAM HOSPITAL	164 SUMMIT AVE	PROVIDENCE	RI	02906	PROVIDENCE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	11/8/2023	NEW	$0
														Subtotal = $598,366

Issue Date FY: 2023 ( Subtotal = $666,686 )
2023	2023	THE MIRIAM HOSPITAL	164 SUMMIT AVE	PROVIDENCE	RI	02906	PROVIDENCE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/7/2023	NEW	$666,686
														Subtotal = $666,686

Grand Total All Awards = $1,879,191

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Control Systems Engineering to Address the Problem of Weight Loss Maintenance: A System Identification Experiment to Model Behavioral & Psychosocial Factors Measured by Ecological Momentary Assessment

Award Number: R01DK137423

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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