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Assessing the impact of exogenous stressors on obesity and pro-inflammatory gene expression

Award Number: R01DK137246
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Assessing the impact of exogenous stressors on obesity and pro-inflammatory gene expression - Obesity has been a persistent public health issue for decades. People with obesity experience higher risk of chronic diseases, such as diabetes, chronic kidney disease, hypertension, coronary heart disease, and stroke. Approximately 42% of adults in the United States currently have obesity. Yet, we still have an inadequate understanding of the etiology of obesity and the upstream drivers that contribute to its development and persistence. Exogenous stress, operating at both interpersonal and residential levels, has been implicated as a potential obesogenic factor. However, the relationship between multiple forms of exogenous stress and adiposity remains understudied. Moreover, the cellular and molecular processes through which such exposures affect physiological function and contribute to excess weight gain are not well understood. This study aims to define the relationship between multiple forms of exogenous stress and adiposity, as well as downstream markers of inflammation, in order to inform prevention and treatment strategies that can reduce obesity across the population. Using data from three large, population-based cohort studies—the National Longitudinal Study of Adolescent to Adult Health, Midlife in the United States, and Health and Retirement Study—we will first assess the associations between residential- and interpersonal-level stress and adiposity indicators (i.e., body mass index and waist circumference). We will then examine whether these exposures are associated with alterations in leukocyte gene expression profiles related to inflammatory pathways, identify relevant cellular and molecular mechanisms, and test whether gene expression mediates the relationship between exogenous stress and adiposity. Finally, we will evaluate the moderating effect of network engagement on these associations. This project will lay the groundwork for future research on exogenous stress and age-related health outcomes, and inform strategies to promote healthier metabolic functioning across the life course.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $533,097 )
2026	2026	NEW YORK UNIVERSITY	70 WASHINGTON SQ S FL 11	NEW YORK	NY	10012	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/24/2026	NON-COMPETING CONTINUATION	$533,097
														Subtotal = $533,097

Issue Date FY: 2025 ( Subtotal = $541,651 )
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/14/2025	NON-COMPETING CONTINUATION	$541,651
														Subtotal = $541,651

Issue Date FY: 2024 ( Subtotal = $556,373 )
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/21/2024	NEW	$556,373
														Subtotal = $556,373

Grand Total All Awards = $1,631,121

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Assessing the impact of exogenous stressors on obesity and pro-inflammatory gene expression

Award Number: R01DK137246

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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