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Advanced Colonoscopy Training Developed Through Manikin Sensorization and Computational Optimization Modeling

Award Number: R01DK137230
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Advanced Colonoscopy Training Developed Through Manikin Sensorization and Computational Optimization Modeling - Project Summary/Abstract More than 19 million colonoscopies are performed in the US each year, with 60% of adults between 55-75 years having at least one within the last decade (1-3). These procedures provide physicians with minimally invasive access to diagnose and treat diseases such as colon cancer. While routine, colonoscopies are the most expensive screening test routinely performed on healthy Americans, with a mean cost of $2,125 (4). Furthering the cost is the wide variation in successful completion rates that occur based on the physician skill– While the acceptable physician success rate is only 90%, this modest target today is only achieved after physicians complete hundreds of patient cases (5-7). In light of this, the investigators have developed the Manikin Advanced Feedback Trainer (MAFT) to improve patient health and reduce healthcare costs through efficient and effective colonoscopy training. Efficient learning is produced using a high fidelity sensorized manikin trainer and a virtual “coach” that uses optimization-based feedback developed through optimization modeling. MAFT is rigorously developed through 3 Aims below: Specific Aim 1: Develop and validate an extensive colon geometry dataset and a refined sensorization system for the MAFT. Colon geometry of 959 patient virtual colonoscopies from The Cancer Imaging Archive (TCIA) will be computationally measured with a user-friendly automated organ geometry centerline program. In addition, this aim will advance MAFT through the refinement of sensor processing. Specific Aim 2: Develop, validate, and execute a 3D optimization model to solve for optimal endoscope steering control. For each specific colon geometry there exists an optimal set of endoscope steering controls to successfully insert an endoscope to reach the cecum in optimal time and with minimal trauma. An Optimization model will be developed to solve for this optimum, and then this program will be executed across the large colon dataset. Specific Aim 3: Develop and experimentally assess virtual coach to provide personalized and progressive learning for the Manikin Advanced Feedback Trainer. Hypothesis (H1): MAFT system of interactive feedback provided by a virtual coach will improve a physician’s cecal intubation rate (CIR), Adenoma Detection Rate (ADR) through improved visualizations, and reduce endoscope forces that can cause colon damage. The virtual coach will be developed and validated through Human Study 1 and 2 that utilizes both attending physicians and residents. In Human Study 3 MAFT will be implemented into the surgical residency program at Hershey Medical Center in Years 4 and 5, and residents’ skills at performing colonoscopy will be assessed based on the well-established metrics of CIR, ADR, and GAGES assessment to validate H1.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $430,116 )
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/7/2025	NON-COMPETING CONTINUATION	$430,116
														Subtotal = $430,116

Issue Date FY: 2024 ( Subtotal = $412,937 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	5/31/2024	NON-COMPETING CONTINUATION	$412,937
														Subtotal = $412,937

Issue Date FY: 2023 ( Subtotal = $471,860 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/22/2023	NEW	$471,860
														Subtotal = $471,860

Grand Total All Awards = $1,314,913

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Advanced Colonoscopy Training Developed Through Manikin Sensorization and Computational Optimization Modeling

Award Number: R01DK137230

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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