Thursday, December 18, 2025 12/18/2025

Orexigenic AgRP neurons in the brainstem

Award Number: R01DK136031
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/04/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Orexigenic AgRP neurons in the brainstem - Project Summary/Abstract Prevalence of obesity is at an all-time high, but treatment methods are still limited. Proper regulation of food intake and body weight rely on coordinated control of orexigenic and anorexigenic neurons in the central nervous system, but our understanding of the neuronal circuits governing feeding is still not complete. Agouti- related protein (AgRP)-expressing neurons are known to be one of the most potent drivers of feeding, and they are currently thought to be exclusively located in the mediobasal hypothalamus. In this application, we present evidence demonstrating the existence of a previously unknown population of AgRP-expressing cells in the area postrema, adjacent subpostrema area and the commissural part of the nucleus of the solitary tract. We further show that these hindbrain AgRP cells potently promote feeding. In this study, we will identify neural substrates that mediate the orexigenic effects of hindbrain AgRP neurons. We will determine how these neurons are regulated by metabolic signals and explore functional redundancy between hindbrain and hypothalamic AgRP neurons. Together, experiments outlined in this proposal will delineate the mechanisms underlying the orexigenic effects of this novel population of AgRP neurons in the brainstem. As such, this study will broaden our knowledge on how central neuronal network operates to control feeding.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $469,832 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	12/16/2025	NON-COMPETING CONTINUATION	$469,832
														Subtotal = $469,832

Issue Date FY: 2025 ( Subtotal = $469,751 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	6/17/2025	NON-COMPETING CONTINUATION	$46,974
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	12/18/2024	NON-COMPETING CONTINUATION	$422,777
														Subtotal = $469,751

Issue Date FY: 2024 ( Subtotal = $478,058 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/1/2024	NEW	$478,058
														Subtotal = $478,058

Grand Total All Awards = $1,417,641

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Orexigenic AgRP neurons in the brainstem

Award Number: R01DK136031

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/04/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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