Friday, April 4, 2025 4/4/2025

Investigating the role of gut extracellular vesicles in diabetic peripheral neuropathy

Award Number: R01DK135970
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Investigating the role of gut extracellular vesicles in diabetic peripheral neuropathy - Abstract Peripheral neuropathy is one of the major complications of diabetes that greatly contribute to morbidity and mortality. Currently, there is no effective treatment for diabetic peripheral neuropathy (DPN). Diabetes at an early stage affects the intestinal microbial composition that promotes the manifestation of metabolic syndrome. However, how gut dysbiosis contributes to the diabetic complications including DPN, is unknown. Extracellular vesicles (EVs) mediate intercellular communication and bacterial EVs retain bacterial genetic and biomaterials. Recent studies show that gut bacterial EVs participate in immune signaling pathways and host metabolic homeostasis that are associated with many disorders. The impact of microbiota derived EVs on DPN has not been investigated. Our preliminary studies demonstrate that gut bacterial EVs participate in the DPN progression. Importantly, our preliminary data also indicate that Lactobacillus-derived EVs alleviate the systemic inflammatory response, protect peripheral nerve damage, and improve neurorecovery in diabetic mice with peripheral neuropathy. In this application, we propose to investigate the effect of gut bacteria-EVs on the development of DPN and to examine the therapeutic potential of Lactobacillus-derived EVs and molecular mechanisms underlying this therapy on neuroinflammation and peripheral nerve damage. These studies will not only significantly expand our understanding of molecular mechanisms underlying gut microbiota-peripheral nerve communication and progression of DPN, but also provide a novel and potentially useful treatment strategy for patients with DPN. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $512,592 )
2025	2025	HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES	426 AUDITORIUM RD	EAST LANSING	MI	48824	INGHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/17/2025	NON-COMPETING CONTINUATION	$512,592
														Subtotal = $512,592

Issue Date FY: 2024 ( Subtotal = $569,477 )
2024	2024	HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES	426 AUDITORIUM RD	EAST LANSING	MI	48824	INGHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/1/2024	NEW	$569,477
														Subtotal = $569,477

Grand Total All Awards = $1,082,069

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Investigating the role of gut extracellular vesicles in diabetic peripheral neuropathy

Award Number: R01DK135970

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer