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SCH: Integrating AI and System Engineering for Glucose Regulation in Diabetes

Award Number: R01DK135116
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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SCH: Integrating AI and System Engineering for Glucose Regulation in Diabetes - The objective of this proposal is to develop a prototype for the next generation multivariable automated insulin delivery (mvAID) systems (also called artificial pancreas) by integrating systems engineering and artificial intelligence (Al) techniques that will mitigate the effects of meals, physical activities ,acute psychological stress inducements and sleep irregularities without manual inputs by the user to tightly regulate the glucose levels of people with diabetes. The first generation of automated insulin delivery (AID) systems relied on hybrid closed-loop technology, collecting data from continuous glucose monitoring devices and requiring manual user inputs for mitigating the effects of meals and exercise. The multivariable AID that we developed provides a well-integrated next-generation system that analyzes historical and realtime data from different sources, including continuous glucose monitoring systems, insulin pumps, and wearable sensors in wristband physical activity trackers, to mitigate the effects of meals, physical activities, and acute psychological stress without manual inputs by the user. Meals, planned exercises, many physical activities of daily living, acute psychological stress, and sleep irregularities affect blood glucose levels differentially, challenging people with Type 1 diabetes to continuously consider all these complex factors in maintaining their blood glucose levels in the target range. Further improvement in glucose regulation can be achieved by developing novel, interpretable, and interactive Al techniques that can explain their predictions to medical care providers and AID users, and by integrating these Al techniques with systems engineering techniques to develop an Al-mvAID system. The function of these Al techniques is to predict the state of a person based on historical trends and current data, and provide additional valuable information to the mvAID system to relieve the users from onerous repetitive tasks for interpreting their current metabolic state, predicting the impact of their current actions on future variations in glucose levels, and tuning the parameters of the Al-mvAID controller. The goal is to produce a powerful userfriendly technology that integrates novel Al techniques with mvAID systems for minimal user burden in achieving tight control of glucose levels despite the many complex glycemic disturbances occurring in freeliving conditions, such as meals, physical activities, acute psychological stress, and sleep irregularities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $296,370 )
2025	2025	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/30/2025	NON-COMPETING CONTINUATION	$296,370
														Subtotal = $296,370

Issue Date FY: 2024 ( Subtotal = $285,717 )
2024	2024	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	8/14/2024	NON-COMPETING CONTINUATION	$285,717
														Subtotal = $285,717

Issue Date FY: 2023 ( Subtotal = $298,737 )
2023	2023	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	8/11/2023	NON-COMPETING CONTINUATION	$0
2023	2023	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	8/9/2023	NON-COMPETING CONTINUATION	$298,737
														Subtotal = $298,737

Issue Date FY: 2022 ( Subtotal = $300,000 )
2022	2022	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/19/2022	NEW	$300,000
														Subtotal = $300,000

Grand Total All Awards = $1,180,824

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SCH: Integrating AI and System Engineering for Glucose Regulation in Diabetes

Award Number: R01DK135116

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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