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Adipocyte cytokine signaling as a coordinator of adipose tissue function

Award Number: R01DK134469
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Adipocyte cytokine signaling as a coordinator of adipose tissue function - Adipose tissue inflammation directly contributes to the overall inflammatory state in obesity, with immune cells being intimately involved regulating adipocyte function and vice versa. The cytokine, oncostatin M (OSM), is produced by adipose tissue macrophages. Our published data suggests that lack of OSM signaling on adipocytes via its receptor (OSMR) leads to adipose tissue inflammation and insulin resistance. Our preliminary data indicate that OSM signaling on adipocytes is required for proper adipose tissue function. The mechanisms adipocytes utilize to regulate adipose tissue inflammation in both health and disease remain unclear. We aim to address this knowledge gap by proposing a new regulatory role for the adipocyte. Specifically, we will test the overarching hypothesis that adipocytes tightly regulate free cytokine availability in AT to maintain insulin sensitivity and limit inflammation. Our recent findings are the basis for the specific aims of this proposal. In these aims, we will test the following hypotheses: (1) OSMR-dependent lipolysis is necessary for maintaining energy balance; (2) continued exposure of adipocytes to OSM results in OSMR desensitization, leading to adipocyte insulin resistance; and (3) excess stromal-derived factor 1 and OSM act on macrophages and preadipocytes, respectively, to promote AT inflammation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $350,000 )
2025	2025	PENNINGTON BIOMEDICAL RESEARCH CENTER	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	6/9/2025	NON-COMPETING CONTINUATION	$350,000
														Subtotal = $350,000

Issue Date FY: 2024 ( Subtotal = $350,000 )
2024	2024	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	7/24/2024	NEW	$0
2024	2024	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/9/2024	NEW	$350,000
														Subtotal = $350,000

Grand Total All Awards = $700,000

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Adipocyte cytokine signaling as a coordinator of adipose tissue function

Award Number: R01DK134469

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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