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Ex-vivo bioengineered technology to unravel dysfunction due to non-alcoholic steatohepatitis (NASH)

Award Number: R01DK132873
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Ex-vivo bioengineered technology to unravel dysfunction due to non-alcoholic steatohepatitis (NASH) - SUPPLEMENT SPECIFIC ABSTRACT This submission is in response to the Research Supplement to Promote Diversity in Health-Related Research (PA-23-189) and is aimed at developing the scientific skills and career development of the candidate. The supplement is requested for grant R01DK132873 “Ex-vivo bioengineered technology to unravel dysfunction due to non-alcoholic steatohepatitis (NASH)”. The parent research project grant centers on the disease NASH that is the progressive form of non-alcoholic fatty liver disease and leads to liver fibrosis by creating an inflammatory milieu that predisposes to liver cancer in the later stages of the disease. The goal of this Research Supplement is to provide high quality mentoring to the candidate along with an invigorating research plan that models liver fibrosis in the laboratory and assess its influence on molecular signaling pathways within iPSC-hepatocytes from patients with and without NASH. Together, this Research Supplement is closely related to the goals of the parent project through the use of already available, de-identified, disease-specific cells and tunable matrix environments. The Research Plan also provides an extension, with an additional line of experimentation to enable the candidate to develop a distinct but related research focus that will become the subject of a future individual training grant. The mentors have a longstanding track record of collaboration in liver research, successful joint mentorship of a trainee and experience with developing the research career of young scientific investigators. The candidate will receive structured mentorship and practical scientific skill development to carry out this hypothesis-driven research that altogether aims to develop a scientific identity for the candidate and maintain trajectory toward a career in academic research. This is enabled by the Research Supplement that provides a pathway for both scientific and career development that is delineated in the Research Plan and Training Plan. While pursuing these research-related end-points, the candidate will receive guidance from the mentoring team on career development objectives that center on: 1) honing scientific communication, both written and oral, 2) professional networking at scientific meetings to expand a cadre of scientific collaborators, and 3) limited classroom education that complements the Research Plan to augment an armamentarium of investigative tools and techniques. Together, this Research Supplement will provide a solid foundation that will launch the candidate’s graduate research trajectory and fortify a strong position for a successful transition into an individual training award as a senior graduate student.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $686,972 )
2025	2025	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/23/2025	NON-COMPETING CONTINUATION	$686,972
2025	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	4/29/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $686,972

Issue Date FY: 2024 ( Subtotal = $736,635 )
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	5/8/2024	NON-COMPETING CONTINUATION	$659,671
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	5/9/2024	SUPPLEMENT FOR EXPANSION	$76,964
														Subtotal = $736,635

Issue Date FY: 2023 ( Subtotal = $700,531 )
2023	2023	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/8/2023	NEW	$700,531
														Subtotal = $700,531

Grand Total All Awards = $2,124,138

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Ex-vivo bioengineered technology to unravel dysfunction due to non-alcoholic steatohepatitis (NASH)

Award Number: R01DK132873

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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