Thursday, March 13, 2025 3/13/2025

Early detection, containment, and management of COVID-19 in dialysis facilities using multi-modal data sources

Award Number: R01DK130067
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract With older age and multiple comorbidities, dialysis patients are at high risk for serious complications, even death, from COVID-19. There is a large disproportionate representation of minorities, especially Blacks and Hispanics. Over 85% of hemodialysis patients travel three times a week to dialysis facilities to receive life-sustaining treatments and cannot shelter in place. There is a critical need to characterize COVID-19 transmission pathways in dialysis patients and clinics, identify potential coronavirus carriers, and develop procedures to curb the spread. With regular medical encounters, a large amount of data has been collected for each patient over time. These data have not been fully utilized for COVID-19 prediction and control in dialysis clinics. In this proposal, we seek to leverage demographic, clinical, treatment, laboratory, socioeconomic, serological, metabolomic, wearable and machine-integrated sensors, and COVID-19 surveillance data to develop mathematical and statistical models and implement them in a large number of dialysis clinics. The mathematical and statistical modeling using multiple data resources will help us understand how COVID-19 spread in dialysis facilities, identify potential COVID-19 patients before symptoms appear, and identify potential asymptomatic COVID-19 patients. We will develop novel mathematical and statistical models that fully utilize the high dimensional multimodal data available to us and other dialysis providers. We capitalize on the intrinsic advantages of hemodialysis clinics to implement and validate the proposed prediction models. We firmly believe that this cross-disciplinary effort will improve patients’ and staff’s safety while delivering high-quality, individualized care to a high-risk population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	000	3	12/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	001	3	10/13/2023	NON-COMPETING CONTINUATION	$0
2024	2021	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	000	1	10/12/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $666,327 )
2023	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	000	3	1/16/2023	NON-COMPETING CONTINUATION	$666,327
2023	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	003	3	2/14/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	002	2	2/2/2023	EXTENSION WITH OR WITHOUT FUNDS	$3
2023	2021	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	001	1	2/2/2023	NEW	-$3
														Subtotal = $666,327

Issue Date FY: 2022 ( Subtotal = $672,811 )
2022	2022	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	002	2	8/3/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2022	2022	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	000	2	1/24/2022	EXTENSION WITH OR WITHOUT FUNDS	$672,811
2022	2021	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	003	1	8/12/2022	NEW	$0
2022	2021	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	001	1	8/2/2022	NEW	$0
														Subtotal = $672,811

Issue Date FY: 2021 ( Subtotal = $652,205 )
2021	2021	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Trans-NIH Research Support	000	1	12/18/2020	NEW	$652,205
														Subtotal = $652,205

Grand Total All Awards = $1,991,343

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Early detection, containment, and management of COVID-19 in dialysis facilities using multi-modal data sources

Award Number: R01DK130067

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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