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Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress

Award Number: R01DK130049
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress - IIT Project Summary/Abstract The objective of this proposal is to demonstrate a viable, functionally integrated multivariable artificial pancreas that will mitigate meal, physical activity and acute psychological stress challenges without any manual inputs to better regulate glucose levels of people with diabetes. The first generation of artificial pancreas (AP) systems, the hybrid closed-loop AP, collects data from continuous glucose monitoring devices and relies on manual user inputs for mitigating the effects of meals and physical activities. Acute psychological stress and many other physical activities besides planned exercise can affect blood glucose levels and cause challenges to maintaining euglycemia for people with type 1 diabetes. Various physical activities and acute psychological stress events affect the metabolism and sensitivity to insulin in different ways. Hence, their types, intensities and durations, and their individual and concurrent presence must be detected in order to determine the optimal insulin administration. The multivariable artificial pancreas approach provides a well-integrated and user-friendly technology with minimal burden on the user and mitigates the effects of unexpected physical activities and acute psychological stress inducements. Additionally, this technology would be safer by reducing the number and duration of hypoglycemic and hyperglycemic events, compared to APs based exclusively on continuous glucose monitoring device data. Such multivariable AP systems can only be developed by using a sophisticated multivariable approach that uses real-time information from continuous glucose monitoring devices and physiological variables obtained from wearable devices worn in free-living daily life.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$1,197 )
2026	2022	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	3/19/2026	NON-COMPETING CONTINUATION	-$1,197
														Subtotal = -$1,197

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $502,959 )
2022	2022	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	7/21/2022	NON-COMPETING CONTINUATION	$502,959
2022	2021	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/20/2022	NEW	$0
														Subtotal = $502,959

Issue Date FY: 2021 ( Subtotal = $515,545 )
2021	2021	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/12/2021	NEW	$515,545
														Subtotal = $515,545

Grand Total All Awards = $1,017,307

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Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress

Award Number: R01DK130049

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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