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Continuous glucose monitoring: determinants and prediction of diabetes mellitus development in the Framingham Heart Study

Award Number: R01DK129305
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Abstract Almost half of adults have either diabetes mellitus (DM) or prediabetes (preDM), but many of those have undiagnosed conditions. Current DM diagnosis and risk prediction are based on single “snapshot” measurements, including fasting blood glucose, postprandial glucose, and hemoglobin (Hb)A1c. However, some individuals that do not fall into high-risk categories by traditional DM biomarkers have occasional glycemic excursions similar to individuals with preDM or even DM. Understanding the determinants of these glycemic patterns and whether they confer risk in developing DM will elucidate the pathophysiology responsible for the progression toward DM and could improve DM risk prediction. We will use continuous glucose monitoring (CGM) to measure glycemic patterns in 2700 adults (mean age 58 years) from the community-based Framingham Heart Study Third Generation cohort and Omni 2, a multi-ethnic cohort. We aim to describe normative glycemic patterns in a large sample of healthy individuals (most of whom do not have DM), exploring how standard clinical measures (body mass index, fasting blood glucose, HbA1c), blood metabolites, gut microbiome, dietary patterns, physical activity, family history of DM, and polygenic risk score for DM relate to CGM-derived glycemic variables. The CGM-derived variables we will explore include time spent in glycemic ranges (e.g. 70-140 mg/dL), hyper/hypoglycemic episodes, mean glucose and glucose variability. Furthermore, we will examine whether CGM-derived glycemic variables predict development of DM over 2-3 years follow-up (through an annual self-reported health history) and relate to prevalence of cardiovascular disease (cross-sectionally). Our study will provide information that could improve the prediction of developing DM and DM complications. Our findings may also lead to new discoveries that will tailor and target prevention of DM.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $424,130 )
2024	2024	TRUSTEES OF BOSTON UNIVERSITY	85 EAST NEWTON ST # M-921	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	3/1/2024	NON-COMPETING CONTINUATION	$397,624
2024	2024	TRUSTEES OF BOSTON UNIVERSITY	85 EAST NEWTON ST # M-921	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	5/6/2024	NON-COMPETING CONTINUATION	$26,506
														Subtotal = $424,130

Issue Date FY: 2023 ( Subtotal = $466,336 )
2023	2023	TRUSTEES OF BOSTON UNIVERSITY	85 E NEWTON ST M-921	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	3/24/2023	NON-COMPETING CONTINUATION	$466,336
														Subtotal = $466,336

Issue Date FY: 2022 ( Subtotal = $499,802 )
2022	2022	TRUSTEES OF BOSTON UNIVERSITY	85 E NEWTON ST M-921	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	1/31/2022	NEW	$499,802
														Subtotal = $499,802

Grand Total All Awards = $1,390,268

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Continuous glucose monitoring: determinants and prediction of diabetes mellitus development in the Framingham Heart Study

Award Number: R01DK129305

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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