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Soluble mediators of relapse

Award Number: R01DK128203
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Soluble mediators of relapse - Abstract The most common event preceding relapse of primary glomerular diseases like Minimal Change Disease and Focal and Segmental Glomerulosclerosis is the common cold. Treatment of disease relapse is a lengthy process involving glucocorticoids and other immunosuppressive medications, some of which have multi-system toxicity. We hypothesized that relapse is induced by a “cytokine storm” that follows infection by common cold viruses like Rhinovirus. A “cytokine cocktail” was designed around the soluble Rhinovirus receptor and induces acute albuminuria after single intravenous injection in mice with low podocyte Zhx2 expression, a common feature in MCD and FSGS patients. This cytokine cocktail comprises of components of the innate and adaptive immune response that are necessary and sufficient to induce acute albuminuria. Exclusion of any member from the cytokine cocktail, or injection of individual members does not induce albuminuria. In this proposal, we will develop therapeutic strategies to prevent relapse of glomerular diseases after a common cold, by depleting soluble cytokines in the cytokine storm, or blocking their receptors in the glomerulus. In Aim 1, studies on cytokine depletion or receptor blockage in the podocyte will be conducted, and receptor dependent and independent mechanisms identified. In Aim 2, studies on cytokine depletion or receptor blockage in endothelial and mesangial cells will be conducted, and receptor dependent and independent mechanisms identified. In Aim 3, a therapeutic strategy that combines cytokine depletion with receptor blockage will be developed.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $527,321 )
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/24/2025	NON-COMPETING CONTINUATION	$527,321
														Subtotal = $527,321

Issue Date FY: 2024 ( Subtotal = $526,098 )
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	5/8/2024	NON-COMPETING CONTINUATION	$526,098
														Subtotal = $526,098

Issue Date FY: 2023 ( Subtotal = $574,221 )
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/7/2023	NON-COMPETING CONTINUATION	$574,221
														Subtotal = $574,221

Issue Date FY: 2022 ( Subtotal = $527,321 )
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	4/19/2022	NON-COMPETING CONTINUATION	$527,321
														Subtotal = $527,321

Issue Date FY: 2021 ( Subtotal = $537,383 )
2021	2021	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	4/21/2021	NEW	$537,383
														Subtotal = $537,383

Grand Total All Awards = $2,692,344

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Soluble mediators of relapse

Award Number: R01DK128203

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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