Friday, November 22, 2024 11/22/2024

Multiparametric ultrasound imaging for early detection of nonalcoholic fatty liver disease

Award Number: R01DK126833
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Liver disease is increasing in numbers and relevance across the globe. This disease causes no noticeable symptoms in many cases. After diagnosis, the costs associated with medical care are very high. Patients can be characterized on the nonalcoholic fatty liver disease (NAFLD) spectrum based on the progressive presence of steatosis (i.e. abnormal accumulation of fat within the liver), inflammation, ballooning, and then hepatic fibrosis. Despite the rapid growth and prevalence, the only therapy to treat NAFLD are lifestyle modifications, such as diet and exercise. While the pharmaceutical industry is actively pursuing the discovery and development of candidate drug therapies to address this unmet medical need, there is an urgent clinical need for the ability to noninvasively detect, accurately stage, and reliably monitor NAFLD. To that end, the goal of this research project is to develop a system and method for multiparametric ultrasound (mpUS) imaging of nonalcoholic fatty liver disease (NAFLD) including early pathology progression. Our preliminary findings strongly suggest that a single mpUS test that combines steatosis, ballooning, and inflammation information has the potential to provide a comprehensive estimation of the main components of early stage NAFLD. The main innovation of the proposed research project lies in the implicit link between biophysical models of NAFLD with these coordinated mpUS measurements. The first objective of this project is to develop an integrated ultrasound system and method for performing mpUS imaging. Then we will optimize this new imaging system in healthy rat liver. Lastly, we will evaluate mpUS imaging with a rat model of NAFLD that mirrors disease progression in humans. Here we will also optimize a biophysical model and longitudinal performance in the decision of NAFLD progression. If successful, this research will introduce and validate a safe, cost-effective mpUS imaging technology that can noninvasively detect, accurately stage, and reliably monitor NAFLD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $388,482 )
2024	2024	TEXAS A&M ENGINEERING EXPERIMENT STATION	3124 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	6/18/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$388,482
2024	2024	TEXAS A&M ENGINEERING EXPERIMENT STATION	3124 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	4	9/4/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$351,298
2024	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/17/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	9/4/2024	NON-COMPETING CONTINUATION	-$351,298
														Subtotal = $388,482

Issue Date FY: 2023 ( Subtotal = $405,421 )
2023	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	1/9/2023	NON-COMPETING CONTINUATION	$40,542
2023	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	12/2/2022	NON-COMPETING CONTINUATION	$364,879
														Subtotal = $405,421

Issue Date FY: 2022 ( Subtotal = $401,747 )
2022	2022	UNIVERSITY OF TEXAS AT DALLAS	800 W CAMPBELL RD	RICHARDSON	TX	75080	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	11/25/2021	NON-COMPETING CONTINUATION	$361,572
2022	2022	UNIVERSITY OF TEXAS AT DALLAS	800 W CAMPBELL RD	RICHARDSON	TX	75080	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	3/29/2022	NON-COMPETING CONTINUATION	$40,175
														Subtotal = $401,747

Issue Date FY: 2021 ( Subtotal = $437,873 )
2021	2021	UNIVERSITY OF TEXAS AT DALLAS	800 W CAMPBELL RD	RICHARDSON	TX	75080	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	12/18/2020	NEW	$437,873
														Subtotal = $437,873

Grand Total All Awards = $1,633,523

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Multiparametric ultrasound imaging for early detection of nonalcoholic fatty liver disease

Award Number: R01DK126833

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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