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Lipidome Remodeling During Development of T1D

Award Number: R01DK123499
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2020
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Lipidome Remodeling During Development of T1D - Project Summary/Abstract DESCRIPTION: Lipids are essential cellular components and act as mediators in cell signaling. The function of lipids is determined by their structures. Dysregulated lipid metabolism is associated with a variety of pathological conditions, including Type 1 Diabetes (T1D). The levels of lipids cannot be predicted by the transcripts or proteins. To understand more about the role of lipids in the development of T1D, an important first step is to directly measure the temporal changes of lipids in an organism that shares similar physiology with human T1D. Built on our technological advancements in comprehensive global lipidomics, targeted lipidomic analysis of lipid mediators, isobaric labeling-based multiplexed analysis of intact glycolipids and determination of C=C unsaturation in intact lipids, in this project, we aim to profile the longitudinal changes of the nonobese diabetic (NOD) mouse lipidome during different stages of T1D development by accomplishing the following: 1) in-depth profile and accurately quantify the major lipids in T1D-pertinent tissues using global lipidomics; 2) use advanced technologies to improve structural resolution, accurately identify and quantify glycolipids and broadly profile bioactive lipid mediators; and 3) compare lipid expression profiles in different tissues and characterize lipidome remodeling during different stages of T1D development. Successfully accomplishing these goals will not only provide invaluable resource to the research community interested in the role of lipids in the development of T1D, but it will also provide better practices for conducting lipidomics research in general.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN ST	GREENSBORO	NC	27412	GUILFORD	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	2/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $340,333 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN ST	GREENSBORO	NC	27412	GUILFORD	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	5/9/2024	NON-COMPETING CONTINUATION	$21,271
2024	2024	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN ST	GREENSBORO	NC	27412	GUILFORD	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	2/22/2024	NON-COMPETING CONTINUATION	$319,062
														Subtotal = $340,333

Issue Date FY: 2023 ( Subtotal = $354,605 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN STREET	GREENSBORO	NC	27412	GUILFORD	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	3/29/2023	NON-COMPETING CONTINUATION	$354,605
														Subtotal = $354,605

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN STREET	GREENSBORO	NC	27412	GUILFORD	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $354,923 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN STREET	GREENSBORO	NC	27412	GUILFORD	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/11/2021	NON-COMPETING CONTINUATION	$354,923
														Subtotal = $354,923

Issue Date FY: 2020 ( Subtotal = $355,469 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN STREET	GREENSBORO	NC	27412	GUILFORD	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/3/2020	NEW	$355,469
														Subtotal = $355,469

Grand Total All Awards = $1,405,330

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Lipidome Remodeling During Development of T1D

Award Number: R01DK123499

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2020

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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