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Neural circuits coordinating protein intake: Role of FGF21

Award Number: R01DK123083
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Neural circuits coordinating protein intake: Role of FGF21 - Project Summary Survival is contingent upon physiologically and behaviorally adapting to a changing nutritional environment, and in mammals this homeostasis is largely mediated by nutritional hormones acting in the brain. Recent decades have seen substantial progress in our understanding of the neural mechanisms mediating energy intake and total food intake, but how animals sense individual macronutrients and self-select between them remains poorly defined. Our lab has recently discovered that the liver-derived hormone FGF21 acts in the brain as a signal of protein status. While normal mice adaptively ‘sense’ protein restriction and alter food intake in order to specifically seek and consume protein, this response is lost in mice lacking FGF21 or brain FGF21 signaling. The project will define the brain areas and neural phenotypes mediating FGF21-dependent changes in feeding behavior, and in doing so will provide the first insight into the neurobiology governing macronutrient choice. Despite the importance of dietary composition and food choice to health, and despite persistent dietary advice to change eating habits, we know almost nothing about how the brain controls dietary macronutrient choice. Thus the work proposed in this application will substantially impact the field by rigorously probing the novel mechanisms controlling feeding behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$1,443 )
2026	2024	PENNINGTON BIOMEDICAL RESEARCH CENTER	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	11/25/2025	NON-COMPETING CONTINUATION	-$1,443
														Subtotal = -$1,443

Issue Date FY: 2024 ( Subtotal = $319,680 )
2024	2024	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	7/15/2024	NON-COMPETING CONTINUATION	$319,680
														Subtotal = $319,680

Issue Date FY: 2023 ( Subtotal = $333,000 )
2023	2023	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/21/2023	NON-COMPETING CONTINUATION	$333,000
														Subtotal = $333,000

Issue Date FY: 2022 ( Subtotal = $333,000 )
2022	2022	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/8/2022	NON-COMPETING CONTINUATION	$333,000
														Subtotal = $333,000

Issue Date FY: 2021 ( Subtotal = $333,000 )
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/12/2021	NON-COMPETING CONTINUATION	$333,000
														Subtotal = $333,000

Issue Date FY: 2020 ( Subtotal = $321,995 )
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/14/2020	NEW	$321,995
														Subtotal = $321,995

Grand Total All Awards = $1,639,232

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Neural circuits coordinating protein intake: Role of FGF21

Award Number: R01DK123083

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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