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American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC)

Award Number: R01DK119199
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/09/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC) - Program Director/Principal Investigator (Last, First, Middle): Shah, Vallabh O and Unruh Mark Despite experiencing high levels of kidney disease compared to other ethnic/racial groups in the United States, American Indians (AIs) continue to receive relatively little attention from researchers studying CKD. An example is the current CRIC study, where less than 1% of participants in this flagship study are AIs. Risk factors for diabetic kidney disease, the predominant form of CKD in this population, include the traditional risk factors of hyperglycemia, hypertension, and inheritance, but also other factors such as exposure to various persistent environmental pollutants. The distribution and determinants of CKD among AIs has been understudied, leaving many questions unanswered about the progression of CKD among AIs, as well as the prevalence of cardiovascular disease (CVD) in the setting of CKD among these populations. This is an urgent issue given the public health impact in AI communities and the relative lack of ongoing research. To address this burden of CKD in Native communities we have formed a consortium of investigators with extensive experience in conducting research of chronic diseases including diabetes, cardiovascular and kidney disease in AIs of Southwestern US. Our proposed CRIC ancillary cohort study of 500 AIs (AI-CRIC) will rapidly improve our understanding of both potential risk factors for CKD progression, as well as the scope of this disease among AIs. This proposal leverages the current CRIC study and incorporates the planned activities of the next phase of the study – “CRIC 2018” – by implementing contemporary CRIC protocols for kidney and cardiovascular measurement and outcomes. The overall goal of the proposed prospective cohort study is to precisely assess the extent to which there are higher rates of CKD/CVD progression in AIs than in other racial/ethnic groups based on standardized definitions used throughout CRIC and relate CKD to the levels of potential environmental and occupational exposures unique to AIs residing in the American Southwest. To better understand the natural history of CKD/CVD in this high-risk population, AI-CRIC will implement the CRIC 2018 protocol of ambulatory monitoring of kidney function and damage along with evaluations of CVD sub-phenotypes using mobile health technologies. We will address these overarching goals with the following specific aims: Specific Aim 1: Conduct a longitudinal study of a CKD cohort of southwest AIs to identify unique risk factors for CKD and CVD progression and compare CKD and CVD event rates and risk factors between AI and other populations represented in CRIC; Specific Aim 2: Conduct ambulatory monitoring of kidney function and damage, and evaluate its relationship with exposure data; Specific Aim 3: Conduct CVD sub-phenotyping using mobile health technologies and evaluate its relationship with exposures data. This proposal takes advantage of the ongoing data collection and expertise of the CRIC study to address a gap in our understanding of CKD progression among AI. Ultimately, AI-CRIC will rapidly inform our understanding of the burden of CKD and provide disparity-reducing interventions. Importantly, the AI-CRIC addresses both an overarching goal of Healthy People 2020 to increase equity and reduce disparities and a priority issue for the American Society of Nephrology. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $614,646 )
2023	2023	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/3/2023	NON-COMPETING CONTINUATION	$614,646
														Subtotal = $614,646

Issue Date FY: 2022 ( Subtotal = $670,432 )
2022	2022	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/26/2022	NON-COMPETING CONTINUATION	$670,432
2022	2022	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	4	9/19/2022	NON-COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	2	8/19/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	8/16/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $670,432

Issue Date FY: 2021 ( Subtotal = $670,586 )
2021	2021	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	7/19/2021	NON-COMPETING CONTINUATION	$670,586
2021	2020	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/19/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	2	7/20/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $670,586

Issue Date FY: 2020 ( Subtotal = $1,059,268 )
2020	2020	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	2	6/30/2020	SUPPLEMENT FOR EXPANSION	$378,748
2020	2020	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	2	6/29/2020	NON-COMPETING CONTINUATION	$680,520
2020	2019	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	6/26/2020	NEW	$0
2020	2019	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/4/2020	NEW	$0
														Subtotal = $1,059,268

Issue Date FY: 2019 ( Subtotal = $696,224 )
2019	2019	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/9/2019	NEW	$696,224
														Subtotal = $696,224

Grand Total All Awards = $3,711,156

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American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC)

Award Number: R01DK119199

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/09/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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