Thursday, April 18, 2024 4/18/2024

Developing Effective Approaches to Extend Hematopoietic Healthspan by Targeting Cell-Extrinsic and Cell-Intrinsic Alterations at Middle Age

Award Number: R01DK118072
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

PROJECT SUMMARY/ABSTRACT The process of aging causes functional decline of the hematopoietic system, including reduced capacity for regeneration, increased risk of infections, and increased risk of certain forms of blood cancer. This is a significant health concern due to the increasing age of our population and incidence of these age-related conditions. No intervention therapies currently exist to extend hematopoietic healthspan with aging, largely due to a lack of understanding of the cellular and molecular alterations that cause functional hematopoietic decline. Our novel approach is to identify cellular and molecular signatures of functional hematopoietic decline at its age of onset, with the rationale that these signatures will point to early causes of decline and hence identify prime targets for extending hematopoietic healthspan. Our preliminary data demonstrate that functional hematopoietic decline occurs by middle age, that alterations in the bone marrow microenvironment at middle age are necessary and sufficient to cause functional hematopoietic decline, and identify alterations in the Insulin-like Growth Factor 1 (IGF1) signaling pathway at middle age as a strong candidate driver of functional hematopoietic decline. This project will use cellular and molecular biological approaches in aging mice to characterize the hematopoietic cell-extrinsic and cell-intrinsic alterations in IGF signaling at middle age that cause functional hematopoietic decline. Results of this project will identify targeted, molecular- and cell type- specific therapeutic strategies to preserve regenerative capacity and immune cell function during aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $615,351 )
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	2/23/2024	COMPETING CONTINUATION	$615,355
2024	2022	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	1/24/2024	NON-COMPETING CONTINUATION	-$4
														Subtotal = $615,351

Issue Date FY: 2022 ( Subtotal = $478,279 )
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/29/2022	NON-COMPETING CONTINUATION	$478,279
														Subtotal = $478,279

Issue Date FY: 2021 ( Subtotal = $477,513 )
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/13/2021	NON-COMPETING CONTINUATION	$477,513
														Subtotal = $477,513

Issue Date FY: 2020 ( Subtotal = $477,513 )
2020	2020	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/15/2020	NON-COMPETING CONTINUATION	$477,513
														Subtotal = $477,513

Issue Date FY: 2019 ( Subtotal = $477,513 )
2019	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/26/2019	NON-COMPETING CONTINUATION	$477,513
														Subtotal = $477,513

Issue Date FY: 2018 ( Subtotal = $473,290 )
2018	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/23/2018	NEW	$473,290
														Subtotal = $473,290

Grand Total All Awards = $2,999,459

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Developing Effective Approaches to Extend Hematopoietic Healthspan by Targeting Cell-Extrinsic and Cell-Intrinsic Alterations at Middle Age

Award Number: R01DK118072

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer