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Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions

Award Number: R01DK115679
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions - Abstract Excessive postprandial glycemia has emerged as a key factor regulating energy intakes and driving obesity and cardiometabolic diseases, and recent studies highlight the rising importance and urgent need of mapping the individual variability of postprandial glycemic response in precision nutrition and diet interventions. The proposed systems study aims to fill this significant research gap. Our study will build upon the unparalleled and complementary resources from three diet intervention trials and cohort: The OmniCarb trial, The POUNDS LOST trial, and The Precision Health Study (PHS). We will analyze associations of the usual levels of fasting plasma metabolome and postprandial metabolomic changes with postprandial glycemic response in the meal challenge tests (Aim 1); and analyze the dynamic changes (5 weeks, 6 and 24 months) in postprandial glycemic variability-related metabolites in response to diet interventions varying in glycemic index (GI) and/or carbohydrate intakes (Aim 2). We will also examine the relations of changes in postprandial glycemic variability-related metabolites with changes in appetite, energy intake and expenditure (Aim 3). In addition, we will examine the temporal sequence and mediation effects of postprandial glycemic variability-related metabolites in the relation between diet interventions and cardiometabolic changes (Aim 4). The proposed project aligns well with the special interest of NIH in ‘Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (NOT-DK-19-019)’ and precision nutrition. Our study will provide novel insights into the intrinsic determinants of individual variability in postprandial glycemic response, and contribute significantly to the development of novel precision diet interventions. The findings from our study will have wide public health applicability and clinical implications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $640,990 )
2026	2026	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	4/3/2026	NON-COMPETING CONTINUATION	$640,990
														Subtotal = $640,990

Issue Date FY: 2025 ( Subtotal = $655,924 )
2025	2025	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	8/4/2025	NON-COMPETING CONTINUATION	$655,924
														Subtotal = $655,924

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	5/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $663,566 )
2023	2023	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	4/24/2023	NON-COMPETING CONTINUATION	$663,566
2023	2022	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	5	6/27/2023	COMPETING CONTINUATION	$804,460
2023	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	4	6/27/2023	NON-COMPETING CONTINUATION	-$642,090
2023	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	6/27/2023	NON-COMPETING CONTINUATION	-$162,370
														Subtotal = $663,566

Issue Date FY: 2022 ( Subtotal = $684,457 )
2022	2022	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	5/10/2022	COMPETING CONTINUATION	$684,457
2022	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	5/9/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $684,457

Issue Date FY: 2021 ( Subtotal = $642,090 )
2021	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	12/8/2020	NON-COMPETING CONTINUATION	$577,881
2021	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	2/3/2021	NON-COMPETING CONTINUATION	$64,209
														Subtotal = $642,090

Issue Date FY: 2020 ( Subtotal = $642,090 )
2020	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	2/10/2020	NON-COMPETING CONTINUATION	$64,209
2020	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	1/6/2020	NON-COMPETING CONTINUATION	$577,881
														Subtotal = $642,090

Issue Date FY: 2019 ( Subtotal = $649,754 )
2019	2019	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	12/6/2018	NON-COMPETING CONTINUATION	$649,754
														Subtotal = $649,754

Issue Date FY: 2018 ( Subtotal = $679,865 )
2018	2018	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	12/28/2017	NEW	$679,865
														Subtotal = $679,865

Grand Total All Awards = $5,258,736

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Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions

Award Number: R01DK115679

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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