Friday, May 9, 2025 5/9/2025

Adipose tissue distribution determines microglial regulation of hippocampal plasticity

Award Number: R01DK110586
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Adipose tissue distribution determines microglial regulation of hippocampal plasticity - PROJECT SUMMARY The ‘apple-shaped’ anatomical pattern that accompanies visceral adiposity increases dementia risk in humans, but the 'pear-shaped' distribution that reflects subcutaneous adiposity does not predict cognitive impairment and may be protective. Several recent studies, including from our lab, have outlined signaling cascades linking peripheral and central inflammation in obesity in males, but vulnerability to obesity-induced metabolic pathology is sexually dimorphic, and susceptibility to neuroinflammation follows similar patterns. Adult females exhibit stronger innate immunity, and evidence from clinical and experimental studies suggests that this dimorphism involves sex differences in anti-inflammatory cytokines. However, current understanding of tissue-specific anti- inflammatory signaling remains rudimentary due to the scarcity of approaches for selective manipulation. Moreover, regionally heterogeneous responses to dietary obesity in different brain areas remain incompletely characterized, leaving open questions surrounding feedforward neuroimmune control versus immunological feedback. The proposed experiments will generate a comprehensive topographical map of neuroimmune responses to chronic overnutrition and elucidate the role of the anti-inflammatory cytokine interleukin-4 in these effects. We will use light-inducible cre drivers and direct delivery of tamoxifen metabolites to selectively manipulate immune cells in cerebrospinal fluid. These technically innovative approaches will be followed by anatomical mapping of lymphocytes and myeloid cells in cleared tissues, single-cell flow cytometric analysis, or analysis of neuronal function at the behavioral and electrophysiological level. Understanding circuit-specific sexual dimorphisms in obesity could yield fundamental insights into the pathogenesis of neuroinflammation in different microenvironments, and could also identify target structures for noninvasive therapeutic modulation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $356,134 )
2025	2025	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	AUGUSTA UNIVERSITY 1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	3/17/2025	NON-COMPETING CONTINUATION	$356,134
2025	2024	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	AUGUSTA UNIVERSITY 1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	3/14/2025	COMPETING CONTINUATION	$47,034
2025	2021	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	AUGUSTA UNIVERSITY 1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	3/14/2025	NON-COMPETING CONTINUATION	-$47,034
														Subtotal = $356,134

Issue Date FY: 2024 ( Subtotal = $392,018 )
2024	2024	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	3/6/2024	COMPETING CONTINUATION	$392,018
2024	2021	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	2/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $392,018

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $342,000 )
2021	2021	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	5/14/2021	NON-COMPETING CONTINUATION	$342,000
														Subtotal = $342,000

Issue Date FY: 2020 ( Subtotal = $342,000 )
2020	2020	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	5/19/2020	NON-COMPETING CONTINUATION	$342,000
														Subtotal = $342,000

Issue Date FY: 2019 ( Subtotal = $342,000 )
2019	2019	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/11/2019	NON-COMPETING CONTINUATION	$342,000
														Subtotal = $342,000

Issue Date FY: 2018 ( Subtotal = $441,125 )
2018	2018	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST # CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	NIH Office of Research on Women's Health	001	2	8/20/2018	SUPPLEMENT FOR EXPANSION	$99,125
2018	2018	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST # CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	6/29/2018	NON-COMPETING CONTINUATION	$342,000
														Subtotal = $441,125

Issue Date FY: 2017 ( Subtotal = $342,000 )
2017	2017	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST # CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/31/2017	NEW	$342,000
														Subtotal = $342,000

Grand Total All Awards = $2,557,277

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Adipose tissue distribution determines microglial regulation of hippocampal plasticity

Award Number: R01DK110586

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer