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Metabolomic and Epigenomic Mechanisms in Developmental Overnutrition.

Award Number: R01DK103246
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2014
PERIOD OF PERFORMANCE END DATE: 07/31/2021

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Metabolomic and Epigenomic Mechanisms in Developmental Overnutrition. - DESCRIPTION (provided by applicant): It is well established that higher maternal circulating glucose results in bigger and fatter babies. The developmental over nutrition hypothesis extends this relationship and suggests that greater maternal fatness, pregnancy fat gain, gestational diabetes and higher maternal circulating glucose and other fuels such as fatty acids, program offspring to life-long greater fatness and adverse metabolic profiles. However, the mechanisms driving this relationship are still unknown. The overarching aim of the proposed work is to determine the role of metabolomics and epigenomic mechanisms in this relationship. This will be achieved using data from two unique and complementary UK birth cohorts: (i) The Avon Longitudinal Study of Parents and Children (ALSPAC) and Born in Bradford (BiB), each with N~ 13,000 index pregnancies. Both cohorts have/will have detailed and complementary data on maternal developmental over nutrition risk factors in pregnancy, maternal metabolomics assessed by NMR spectroscopy on pregnancy samples, fetal metabolomics assessed using cord blood serum, as well as on serum from several time points during infancy and adolescence. Offspring genome wide methylation patterns have been determined in cord blood white cells and again in childhood and adolescence. Measures of adiposity and metabolic health have been assessed repeatedly from birth to early adulthood. Moreover, ALSPAC offspring are now in their mid-20s and are having children of their own, enabling the investigation of the relationship between maternal risk factors for developmental over nutrition and offspring adiposity and metabolic health across two generations. The work proposed here will identify targets for interventions aimed at reducing the adverse impacts of developmental over nutrition on future generations. Given that 20-50% of women who start pregnancy are overweight or obese and that 15% of pregnancies are affected by GDM, this is extremely important. This work will also develop a framework for the appropriate analyses of large repeatedly assessed multi-'omic' data in birth cohorts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2018	UNIVERSITY OF BRISTOL	BEACON HOUSE	BRISTOL				GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	11/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$136,001 )
2022	2018	UNIVERSITY OF BRISTOL	BEACON HOUSE	BRISTOL				GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	12/23/2021	NON-COMPETING CONTINUATION	-$136,001
														Subtotal = -$136,001

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	UNIVERSITY OF BRISTOL	BEACON HOUSE	BRISTOL		BS8 1QU		GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	4/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $424,463 )
2018	2018	UNIVERSITY OF BRISTOL	SENATE HOUSE	BRISTOL	AVON	BS8 1TH		GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	9/14/2018	NON-COMPETING CONTINUATION	$424,463
														Subtotal = $424,463

Issue Date FY: 2017 ( Subtotal = $444,011 )
2017	2017	UNIVERSITY OF BRISTOL	SENATE HOUSE	BRISTOL	AVON	BS8 1TH		GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/21/2017	NON-COMPETING CONTINUATION	$444,011
														Subtotal = $444,011

Issue Date FY: 2016 ( Subtotal = $451,329 )
2016	2016	UNIVERSITY OF BRISTOL	TYNDALL AVENUE SECRETARY`S OFF	BRISTOL BS 81 TH				GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/6/2016	NON-COMPETING CONTINUATION	$451,329
														Subtotal = $451,329

Issue Date FY: 2015 ( Subtotal = $451,077 )
2015	2015	UNIVERSITY OF BRISTOL	TYNDALL AVENUE SECRETARY`S OFF	BRISTOL BS 81 TH				GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/22/2015	NON-COMPETING CONTINUATION	$451,077
														Subtotal = $451,077

Issue Date FY: 2014 ( Subtotal = $459,985 )
2014	2014	UNIVERSITY OF BRISTOL	TYNDALL AVENUE SECRETARY`S OFF	BRISTOL BS 81 TH				GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/11/2014	NEW	$459,985
														Subtotal = $459,985

Grand Total All Awards = $2,094,864

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Metabolomic and Epigenomic Mechanisms in Developmental Overnutrition.

Award Number: R01DK103246

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2014

PERIOD OF PERFORMANCE END DATE: 07/31/2021

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