Thursday, November 21, 2024 11/21/2024

Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut Microbiota

Award Number: R01DK100383
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Compelling evidence has implicated human gut microbiota in development of obesity and related cardiometabolic disorders. Recent studies identified a group of circulating metabolites that are functionally related to gut microbiota. These microbial metabolites act as ‘transducers’ in the microbiota-host communications and ‘sensors’ in gut-organ/tissue crosstalk, and affect ectopic fat distribution in various metabolic organs and tissues. Diet is among the most important regulators of gut microbiota; however, no study has assessed how weight-loss diets may affect the long-term changes of the newly identified microbial metabolites. The proposed systems study aims to fill this significant research gap. In two of the longest and largest comparator trials on the popular weight-loss diets - POUNDS LOST and CENTRAL, we propose to identify novel plasma microbial metabolites associated with long-term weight loss in response to diet interventions. We will examine relations of plasma levels of identified microbial metabolites and ectopic fat distribution in the liver, heart, pancreas, and kidney, as well as adipose and skeletal muscle tissues. In addition, we will assess whether changes in plasma microbial metabolites mediate the relations between weight loss and changes in cardiometabolic markers. Moreover, we will examine the dynamic associations between microbial metabolites and changes in plasma miRNAs related to obesity and cardiometabolic risk. The findings from our study will considerably improve development of novel prevention and treatment strategies for obesity and related cardiometabolic disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $595,353 )
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	5/6/2024	NON-COMPETING CONTINUATION	$595,353
														Subtotal = $595,353

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	1/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $620,160 )
2022	2022	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	11/18/2021	NON-COMPETING CONTINUATION	$558,143
2022	2022	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	3/29/2022	NON-COMPETING CONTINUATION	$62,017
														Subtotal = $620,160

Issue Date FY: 2021 ( Subtotal = $620,160 )
2021	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	2/3/2021	NON-COMPETING CONTINUATION	$62,017
2021	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	12/2/2020	NON-COMPETING CONTINUATION	$558,143
2021	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	006	5	8/8/2021	COMPETING CONTINUATION	$1
2021	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	5	2/9/2021	COMPETING CONTINUATION	$541,316
2021	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	4	2/9/2021	NON-COMPETING CONTINUATION	-$322,193
2021	2016	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	2/9/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$219,123
2021	2016	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	3	8/8/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1
														Subtotal = $620,160

Issue Date FY: 2020 ( Subtotal = $651,456 )
2020	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	3/9/2020	COMPETING CONTINUATION	$651,456
2020	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	3/10/2020	COMPETING CONTINUATION	$0
2020	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	3/5/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $651,456

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	8/7/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $322,193 )
2017	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	4	8/30/2017	NON-COMPETING CONTINUATION	$322,193
2017	2016	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	2/16/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$824,904
2017	2015	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	2/16/2017	NON-COMPETING CONTINUATION	-$515,471
2017	2014	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/16/2017	NEW	-$309,433
														Subtotal = $322,193

Issue Date FY: 2016 ( Subtotal = $437,302 )
2016	2016	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	9/5/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$437,302
														Subtotal = $437,302

Issue Date FY: 2015 ( Subtotal = $515,471 )
2015	2015	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/3/2015	NON-COMPETING CONTINUATION	$515,471
														Subtotal = $515,471

Issue Date FY: 2014 ( Subtotal = $454,897 )
2014	2014	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/4/2014	NEW	$454,897
														Subtotal = $454,897

Grand Total All Awards = $4,216,992

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Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut Microbiota

Award Number: R01DK100383

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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