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SKIN-CNS-BLADDER REFLEX ARC FOR MICTURITION AFTER SCI

Award Number: R01DK053063
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/1999
PERIOD OF PERFORMANCE END DATE: 12/31/2004

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SKIN-CNS-BLADDER REFLEX ARC FOR MICTURITION AFTER SCI - The neurological bladder caused by spinal cord injury (SCI) presents a significant medical and social problem. There is no satisfactory treatment yet. Supported by the Paralyzed Veterans of America and NIH, a new reflex pathway, "Skin-CNS-Bladder" for controlled micturition after SCI has been successfully established in rat, cat and canine models. Preliminary clinical application of 14 SCI patients also provided very promising results. The study proposed here is to transfer the Skin-CNS-Bladder reflex functions. The ventral root (VR) of a lumbar nerve (L5) below the spinal cord lesion will be anastomosed to the sacral VR (S2 and/or S3) which innervate the bladder, while leaving the intact L5 dorsal root (DR) as a started of micturition. After the axonal regeneration, controllable voiding would be initiated by scratching the L4 dermatome. Effect of the new reflex pathway on bladder function will be evaluated by means of electrophysiology and urodynamics. Its effect on bowel and sexual functions will also be studied. The procedure may revolutionize the treatment of neurogenic bladder after SCI, It requires relatively minor surgery on 2 paralyzed nerves. It does not involve implantation of electrodes or other devices but provides unique voluntary control of bladder emptying. Scientifically, the study will further prove the new concept derived from the unique somatic-autonomic reflex that the impulses delivered from the efferent neurons of a somatic reflex arc may be transferred to initiate response of an autonomic effector. This new concept may be widely useful, not only for neurogenic bladder, but also for other problems caused by the spinal cord injury or diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $642,796 )
2004	2004	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Kidney Diseases, Urology and Hematology Research	000	5	1/16/2004	NON-COMPETING CONTINUATION	$642,796
														Subtotal = $642,796

Issue Date FY: 2003 ( Subtotal = $625,059 )
2003	2003	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Kidney Diseases, Urology and Hematology Research	000	4		NON-COMPETING CONTINUATION	$625,059
														Subtotal = $625,059

Issue Date FY: 2002 ( Subtotal = $607,462 )
2002	2002	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Kidney Diseases, Urology and Hematology Research	000	3	12/24/2001	NON-COMPETING CONTINUATION	$607,462
														Subtotal = $607,462

Issue Date FY: 1999 ( Subtotal = $549,964 )
1999	1999	LONG ISLAND COLLEGE HOSPITAL	339 HICKS STREET	BROOKLYN	NY	11201	KINGS	USA	Kidney Diseases, Urology and Hematology Research	000	1	9/24/1999	NEW	$549,964
														Subtotal = $549,964

Grand Total All Awards = $2,425,281

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SKIN-CNS-BLADDER REFLEX ARC FOR MICTURITION AFTER SCI

Award Number: R01DK053063

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/1999

PERIOD OF PERFORMANCE END DATE: 12/31/2004

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