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Adapting Diabetes Treatment Expert Systems to Patient's Expectations and Psychobehavioral Characteristics in Type 1 Diabetes

Award Number: R01DK051562
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Adapting Diabetes Treatment Expert Systems to Patient's Expectations and Psychobehavioral Characteristics in Type 1 Diabetes - Adapting Diabetes Treatment Expert Systems to Patient's Expectations and Psychobehavioral Characteristics in Type 1 Diabetes. Glucose variability (GV) in type 1 diabetes (T1DM) is commonly viewed as a primary marker of glycemic control, potentially responsible, along with chronic hyperglycemia, for diabetes complications. This proposed project continues 20 years of research, which identified physiological and behavioral correlates of GV and successfully tested feedback control policies to reduce GV via simultaneous protection against hypoglycemia and systematic hyperglycemia in T1DM. Our primary hypothesis is that: Reducing glucose variability in T1DM can be optimally achieved by technology that is informed of, and adapted to, the individual psychobehavioral and metabolic profiles of patients/users. This can be achieved through personalization and automated adaptation of treatment policies, and through treatment intervention that corresponds to each patient's level of technology acceptance and is designed to maximize successful system use by tracking and reinforcing trust in the intervention. Therefore, in this project we plan to (i) confirm the efficacy of two previously designed technological interventions - Informative Decision Support System (iDSS) and Prescriptive Decision Support System (pDSS) - in reducing GV in T1DM patients during a 6-month long randomized cross-over clinical trial; (ii) show that subjects participating in this study will have technology intervention preferences (e.g. iDSS vs pDSS) that can be predicted by key parameters of their psychobehavioral profile and are prognostic of the level of GV control achievable by the intervention; and finally, we propose to define and validate a novel, measureable, index of technology acceptance and trust, by automatically observing user/system interactions. In summary, this project will demonstrate that CGM-based decision support systems can significantly reduce GV in T1DM, and that performance is predicted by psychobehavioral characteristics and expectations. We further introduce a novel index tracking technology acceptance and trust, predictive of system performance. Such index would ultimately enable future optimal self-adaptation of automated treatment strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $490,802 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	1/26/2023	NON-COMPETING CONTINUATION	$490,802
														Subtotal = $490,802

Issue Date FY: 2022 ( Subtotal = $657,313 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	4/6/2022	NON-COMPETING CONTINUATION	$65,731
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	1/20/2022	NON-COMPETING CONTINUATION	$591,582
														Subtotal = $657,313

Issue Date FY: 2021 ( Subtotal = $672,867 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	2/9/2021	NON-COMPETING CONTINUATION	$672,867
														Subtotal = $672,867

Issue Date FY: 2020 ( Subtotal = $687,883 )
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	2/10/2020	NON-COMPETING CONTINUATION	$68,788
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	1/24/2020	NON-COMPETING CONTINUATION	$619,095
														Subtotal = $687,883

Issue Date FY: 2019 ( Subtotal = $701,845 )
2019	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	3/28/2019	COMPETING CONTINUATION	$701,845
														Subtotal = $701,845

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	11/17/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $380,709 )
2015	2015	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	6/16/2015	NON-COMPETING CONTINUATION	$380,709
														Subtotal = $380,709

Issue Date FY: 2014 ( Subtotal = $380,709 )
2014	2014	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	6/25/2014	NON-COMPETING CONTINUATION	$380,709
														Subtotal = $380,709

Issue Date FY: 2013 ( Subtotal = $396,264 )
2013	2013	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	6/25/2013	NON-COMPETING CONTINUATION	$396,264
														Subtotal = $396,264

Issue Date FY: 2012 ( Subtotal = $407,531 )
2012	2012	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	9/21/2012	COMPETING CONTINUATION	$407,531
														Subtotal = $407,531

Issue Date FY: 2010 ( Subtotal = $4,000 )
2010	2010	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Trans-NIH Recovery Act Research Support	000	14	1/1/2010	SUPPLEMENT FOR EXPANSION	$4,000
														Subtotal = $4,000

Issue Date FY: 2009 ( Subtotal = $482,952 )
2009	2009	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	6/24/2009	NON-COMPETING CONTINUATION	$482,952
														Subtotal = $482,952

Issue Date FY: 2008 ( Subtotal = $483,846 )
2008	2008	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	6/18/2008	NON-COMPETING CONTINUATION	$483,846
														Subtotal = $483,846

Issue Date FY: 2007 ( Subtotal = $482,958 )
2007	2007	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	5/16/2007	NON-COMPETING CONTINUATION	$482,958
														Subtotal = $482,958

Issue Date FY: 2006 ( Subtotal = $485,035 )
2006	2006	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	5/10/2006	NON-COMPETING CONTINUATION	$485,035
														Subtotal = $485,035

Issue Date FY: 2005 ( Subtotal = $490,121 )
2005	2005	UNIVERSITY OF VIRGINIA	PO BOX 9003	CHARLOTTESVILLE	VA	22906	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	4/18/2005	COMPETING CONTINUATION	$490,121
														Subtotal = $490,121

Issue Date FY: 2004 ( Subtotal = $331,272 )
2004	2004	UNIVERSITY OF VIRGINIA	PO BOX 9003	CHARLOTTESVILLE	VA	22906	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	6/21/2004	NON-COMPETING CONTINUATION	$331,272
														Subtotal = $331,272

Issue Date FY: 2003 ( Subtotal = $331,272 )
2003	2003	UNIVERSITY OF VIRGINIA	PO BOX 9003	CHARLOTTESVILLE	VA	22906	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	6/9/2003	NON-COMPETING CONTINUATION	$331,272
														Subtotal = $331,272

Issue Date FY: 2002 ( Subtotal = $333,000 )
2002	2002	UNIVERSITY OF VIRGINIA	PO BOX 9003	CHARLOTTESVILLE	VA	22906	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	6/24/2002	NON-COMPETING CONTINUATION	$333,000
														Subtotal = $333,000

Issue Date FY: 2001 ( Subtotal = $333,000 )
2001	2001	UNIVERSITY OF VIRGINIA	PO BOX 9003	CHARLOTTESVILLE	VA	22906	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	6/8/2001	COMPETING CONTINUATION	$333,000
														Subtotal = $333,000

Issue Date FY: 2000 ( Subtotal = $73,863 )
2000	2000	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	7/21/2000	NON-COMPETING CONTINUATION	$73,863
														Subtotal = $73,863

Issue Date FY: 1999 ( Subtotal = $71,980 )
1999	1999	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	6/9/1999	NON-COMPETING CONTINUATION	$71,980
														Subtotal = $71,980

Issue Date FY: 1998 ( Subtotal = $64,365 )
1998	1998	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	9/11/1998	COMPETING CONTINUATION	$64,365
														Subtotal = $64,365

Grand Total All Awards = $8,743,587

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Adapting Diabetes Treatment Expert Systems to Patient's Expectations and Psychobehavioral Characteristics in Type 1 Diabetes

Award Number: R01DK051562

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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