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Determining the Impact of Metabolic Syndrome on the Oral Microbiome and Periodontal Health Using a Longitudinal Systems Biology Approach

Award Number: R01DE034679
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2026
PERIOD OF PERFORMANCE END DATE: 12/31/2030

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Determining the Impact of Metabolic Syndrome on the Oral Microbiome and Periodontal Health Using a Longitudinal Systems Biology Approach - Project Summary Metabolic Syndrome (MetS) affects over one-third of U.S. adults and is closely linked with oral health issues, particularly periodontitis. The bidirectional relationship between MetS and periodontitis exacerbates both conditions, but the underlying mechanisms remain unclear. Our preliminary R03 data indicate that MetS alters the oral microbiome, creating an ‘at-risk-for-harm’ environment even in the absence of clinical periodontal disease. This project aims to elucidate these mechanisms through a longitudinal systems biology approach, focusing on how restoring metabolic health impacts the functional oral ecosystem. We hypothesize that improved metabolic health will shift the oral microbiome towards a eubiotic state, reduce pathogenic strains, and alter the metabolome to a less inflammatory profile. We test our hypothesis in the following specific aims. In Specific Aim 1: We will track the oral microbiome's temporal dynamics in MetS and Metabolically Healthy Obese (MHO) cohorts undergoing lifestyle or surgical interventions, comparing them with healthy and periodontal disease cohorts. In Specific Aim 2: We will analyze changes in the oral metabolome post-metabolic intervention using advanced mass spectrometry techniques. In Specific Aim 3: We aim to identify and validate oral biomarkers and risk indicators linked to metabolic health improvements. This study will use a causal mediation framework to explore direct and indirect effects, providing crucial insights into the MetS-periodontal health relationship and aiding in the development of prognostic biomarkers and risk indicators in the future.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $699,184 )
2026	2026	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Oral Diseases and Disorders Research	001	1	1/26/2026	NEW	$0
2026	2026	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Oral Diseases and Disorders Research	000	1	1/15/2026	NEW	$699,184
2026	2026	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Oral Diseases and Disorders Research	002	1	2/18/2026	NEW	$0
														Subtotal = $699,184

Grand Total All Awards = $699,184

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Determining the Impact of Metabolic Syndrome on the Oral Microbiome and Periodontal Health Using a Longitudinal Systems Biology Approach

Award Number: R01DE034679

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2026

PERIOD OF PERFORMANCE END DATE: 12/31/2030

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