Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Therapeutic mechanisms of iPSC-MSC derived extracellular vesicles on dry mouth caused by Sjorgren's syndrome or radiotherapy

Award Number: R01DE032028
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/13/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2030

Group Awards By:

View Award Description

Therapeutic mechanisms of iPSC-MSC derived extracellular vesicles on dry mouth caused by Sjorgren's syndrome or radiotherapy - Project Summary The long lasting decrease of saliva secretion, also called dry mouth, is common in patients with Sjögren's syndrome (an autoimmune disease affecting salivary glands) or treated with radiation therapy for head and neck cancer. This side effect significantly impairs the quality of life and is difficult to remedy. Mesenchymal stem/stromal cells (MSCs) are conventionally isolated from tissues and capable of inhibiting autoimmune responses and promoting regeneration, and have shown therapeutic efficacies in both types of dry mouth. However, there are many limitations of using tissue-derived MSCs directly for therapies including their high variations and limited expandability. The applicant’s recent work revealed that MSCs derived from human induced pluripotent stem cells (iMSCs) are highly standardized and can be produced at a large scale. Extracellular vesicles (EVs) are nano-sized particles released from cells spontaneously. EVs carry bioactive molecules similar to their originating cells, and are much safer and more feasible for clinical application compared to their originating cells. iMSCs and their EVs showed immunosuppressive and pro-regenerative effects comparable to the best tissue-derived MSCs. This proposal aims to determine therapeutic potentials and mechanisms of iMSC EVs on both types of dry mouth. First, this project will determine therapeutic mechanisms of systemically infused iMSC EVs on Sjögren's syndrome. Second, this project will determine therapeutic mechanisms of locally infused iMSC EVs on the restoration of saliva secretion after local radiation. The success of proposed research will provide the proof-of-concept and the guide of optimization for novel and clinically feasible therapies of Sjögren's syndrome and dry mouth caused by radiation therapy. These outcomes will also encourage further research on similar therapies for other autoimmune diseases and radiation damages to other healthy organs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $640,889 )
2026	2026	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Oral Diseases and Disorders Research	000	2	6/3/2026	NON-COMPETING CONTINUATION	$640,889
														Subtotal = $640,889

Issue Date FY: 2025 ( Subtotal = $643,574 )
2025	2025	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Oral Diseases and Disorders Research	000	1	8/13/2025	NEW	$643,574
														Subtotal = $643,574

Grand Total All Awards = $1,284,463

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Therapeutic mechanisms of iPSC-MSC derived extracellular vesicles on dry mouth caused by Sjorgren's syndrome or radiotherapy

Award Number: R01DE032028

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/13/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer