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SCH: Multidimensional Microfluidic Salivary Sensor with Adversarial Knowledge Distillation for Point-of-Care Assessment of Periodontitis and Comorbidities

Award Number: R01DE031832
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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SCH: Multidimensional Microfluidic Salivary Sensor with Adversarial Knowledge Distillation for Point-of-Care Assessment of Periodontitis and Comorbidities - The goal of this research is to develop a sensor device prototype to rapidly measure an array of diverse salivary biomarkers as input for novel machine learning (ML) methods that can predict periodontitis and monitor periodontal progression. Our long-term goal is to develop a rapid, user-friendly, and low-cost point-of-care (POC) device, for use in either a dentist’s office or at home, that rapidly integrates and analyzes data to support patient management. It addresses the priority area of the Data Science, Computational Biology, and Bioinformatics Program of NIDCR in integrating and analyzing high-volume and diverse data to better understand dental, oral, and craniofacial biology and diseases. According to the CDC, nearly 50% adults have some form of periodontal disease. Perioodontitis is silently progressive and patients often seek professional care only in an advanced stage where advanced, painful and costly procedures are needed to control disease or replace lost teeth. Early detection of periodontal disease at an individual patient level is required and there is growing awareness that multiple biomarkers are valued in predicting risk of disease in individuals. We hypothesize that predictive models can be established based on the measurements of a large set of periodontitis-associated biomarkers in saliva; a sensor device that integrates multi-sensor modalities and the machine learning (ML) models will advance the clinical goal of early diagnosis of periodontitis to enable earlier clinical interventions. Thus, we will develop and apply three distinctive sensor modalities for detecting concentrations of salivary analytes relevant to various stages of periodontal progression, i.e., inflammation, soft tissue destruction or bone destruction (Aim 1). Data from both sensor outputs and clinical examination will be used to train ML models via a novel multi-modal adversarial knowledge distillation ML framework, which promotes accurate early prediction with partial longitudinal data representations (Aim 2). The multi-sensor modalities and the ML models will be embedded in a single microfluidic device, incorporating steps such as sampling, detection, and data analysis as an integrated lab-on-a-chip, and permitting the sensor data preprocessed to transmit only the actionable information to the outside platform to protect the user's privacy (Aim 3). Such a device is anticipated to offer for unobtrusive, accurate, and frequent saliva-based self-monitoring, and provide detailed medical data to support clinical decisions. It will be an effective tool for future personalized medicine and dramatically improve patients' oral health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	000	4	1/30/2026	NON-COMPETING CONTINUATION	-$287,077
2026	2024	WORCESTER POLYTECHNIC INSTITUTE	100 INSTITUTE RD	WORCESTER	MA	01609	WORCESTER	USA	Oral Diseases and Disorders Research	002	5	6/23/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2026	2024	WORCESTER POLYTECHNIC INSTITUTE	100 INSTITUTE RD	WORCESTER	MA	01609	WORCESTER	USA	Oral Diseases and Disorders Research	001	5	2/2/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$287,077
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $371,786 )
2024	2024	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	000	4	8/14/2024	NON-COMPETING CONTINUATION	$287,078
2024	2024	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	001	4	8/19/2024	SUPPLEMENT FOR EXPANSION	$84,708
														Subtotal = $371,786

Issue Date FY: 2023 ( Subtotal = $382,939 )
2023	2023	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	002	3	8/21/2023	SUPPLEMENT FOR EXPANSION	$84,708
2023	2023	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	001	3	8/18/2023	NON-COMPETING CONTINUATION	$298,231
2023	2022	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	000	2	8/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $382,939

Issue Date FY: 2022 ( Subtotal = $295,775 )
2022	2022	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	001	2	8/17/2022	NON-COMPETING CONTINUATION	$295,775
2022	2021	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	000	1	11/8/2021	NEW	$0
														Subtotal = $295,775

Issue Date FY: 2021 ( Subtotal = $299,999 )
2021	2021	ILLINOIS INSTITUTE OF TECHNOLOGY	10 W 35TH ST	CHICAGO	IL	60616	COOK	USA	Oral Diseases and Disorders Research	000	1	9/23/2021	NEW	$299,999
														Subtotal = $299,999

Grand Total All Awards = $1,350,499

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SCH: Multidimensional Microfluidic Salivary Sensor with Adversarial Knowledge Distillation for Point-of-Care Assessment of Periodontitis and Comorbidities

Award Number: R01DE031832

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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