Thursday, October 17, 2024 10/17/2024

Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy

Award Number: R01DE031478
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The long lasting decrease of saliva secretion, also called dry mouth, is common in patients treated with radiotherapy for head and neck cancer. This side effect significantly impairs the quality of life of affected patients and is difficult to remedy. The applicant’s recent work revealed that macrophages abundant in salivary glands are sharply damaged by radiotherapy, and their recovery is required for restoring saliva secretion. The goals of this proposal are to determine the roles of local macrophages in the development, maintenance and regeneration of salivary glands, and how these cells respond to radiation and restore salivary function damaged by radiation. To achieve these goals, this project will trace the origin of local macrophages under conditions mentioned above, determine effects of removing these cells on salivary function, and pinpoint which molecules are responsible for the damage of these cells by radiation and for the recovery of salivary function damaged by radiation. Completion of this project will reveal vital roles of local macrophages and their products in the maintenance of saliva secretion, and form a basis for developing novel and feasible approaches to treating dry mouth caused by radiotherapy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $352,616 )
2024	2024	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Oral Diseases and Disorders Research	000	4	6/4/2024	NON-COMPETING CONTINUATION	$352,616
														Subtotal = $352,616

Issue Date FY: 2023 ( Subtotal = $359,813 )
2023	2023	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Oral Diseases and Disorders Research	000	3	6/2/2023	NON-COMPETING CONTINUATION	$359,813
														Subtotal = $359,813

Issue Date FY: 2022 ( Subtotal = $356,214 )
2022	2022	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Oral Diseases and Disorders Research	000	2	6/2/2022	NON-COMPETING CONTINUATION	$356,214
														Subtotal = $356,214

Issue Date FY: 2021 ( Subtotal = $359,813 )
2021	2021	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Oral Diseases and Disorders Research	000	1	9/20/2021	NEW	$359,813
														Subtotal = $359,813

Grand Total All Awards = $1,428,456

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Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy

Award Number: R01DE031478

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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