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Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach

Award Number: R01DE031476
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach - ” Periodontitis (gum disease) is a ubiquitous chronic inflammatory, bacteria-triggered oral disorder affecting two-thirds of Americans over age 65. If left untreated, it leads to severe destruction of the periodontal attachment apparatus, eventually resulting in tooth loss. There are no approaches for predictably regenerating defects with severe bone loss and avoiding tooth extraction. Thus, there is an emerging quest for personalized solutions that can guide coordinated growth and development of the periodontal attachment apparatus. We hypothesize that: (1) Melt ElectroWriting (MEW) is the fabrication tool required to develop a compositionally and structurally tailored, tissue-specific scaffold to hearten bone growth and PDL formation on root surfaces with moderate adjacent bone; and (2) the convergence of MEW with ceramic printing is key to engineering a compositionally graded and structurally tailored scaffold to support bone growth while guiding PDL formation on root surfaces with minimum adjacent bone. Two aims are proposed. Aim 1 will optimize a personalized, compositionally and structurally tailored, tissue-specific polymeric scaffold to regenerate defects with moderate surrounding bone. Aim 2 will develop a personalized, compositionally graded and structurally tailored, tissue-specific multi-material scaffold to regenerate defects with minimum surrounding bone. To expedite translation, we will determine efficacy using our clinically relevant animal models. Successful completion of this project is central to translating personalized therapies to treat tissue destruction caused by periodontitis and thus saving millions of teeth from extraction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $482,174 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	4	3/21/2025	NON-COMPETING CONTINUATION	$482,174
														Subtotal = $482,174

Issue Date FY: 2024 ( Subtotal = $484,624 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	3	6/5/2024	NON-COMPETING CONTINUATION	$39,560
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	3	4/22/2024	NON-COMPETING CONTINUATION	$445,064
														Subtotal = $484,624

Issue Date FY: 2023 ( Subtotal = $501,127 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	2	4/5/2023	NON-COMPETING CONTINUATION	$501,127
														Subtotal = $501,127

Issue Date FY: 2022 ( Subtotal = $515,127 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	1	7/20/2022	NEW	$515,127
														Subtotal = $515,127

Grand Total All Awards = $1,983,052

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Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach

Award Number: R01DE031476

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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