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Precision imaging for risk stratification and personalized therapy of oropharyngeal cancer

Award Number: R01DE030894
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/05/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Precision imaging for risk stratification and personalized therapy of oropharyngeal cancer - ABSTRACT During the past few decades, there has been a rapid increase in the incidence of oropharyngeal cancer (OPC), which is attributable to the epidemic of oral human papillomavirus (HPV) infection. Patients with HPV-positive OPC respond well to concurrent chemoradiotherapy and have a more favorable prognosis than HPV-negative patients. However, standard treatment is associated with significant toxicity and likely represents over-treatment for many patients with HPV-positive disease. Several randomized clinical trials have tested novel deintensification strategies with the goal to reduce toxicity and improve patients’ quality of life while preserving the high cure rate. These trials enroll patients based on cancer stage and smoking history. However, current clinical prognostic factors are rather crude and do not accurately predict disease progression on an individual level. Reliable prognostic models are critically needed for personalized risk-adaptive therapy of OPC. To address this unmet need, we propose quantitative CT features to characterize intratumoral spatial heterogeneity and disease invasion/spread, which are known drivers of treatment resistance and disease progression. In addition to knowledge-based image features, we will develop complementary data-driven deep learning models to predict disease progression by using a retrospective multi- institutional dataset of 1771 patients. Further, we will integrate imaging with clinical data to improve prediction and establish their validity by rigorous prospective validation in 1780 patients enrolled in 3 randomized clinical trials. Finally, we will employ a radiogenomic approach to elucidate biological basis of the imaging signatures. If successful, the proposed models will allow more accurate prediction of prognosis and improve risk stratification of OPC. This has significant therapeutic implications by optimizing the selection of patients for treatment deintensification, which will increase the likelihood of success of future clinical trials and pave the way for precision medicine in OPC. Because the information is derived from standard CT scans, this would be readily integrated into current clinical workflow, widely applicable to underserved populations in low-resource settings, and therefore would help reduce health disparity in the US.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $606,419 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Oral Diseases and Disorders Research	000	5	4/3/2026	NON-COMPETING CONTINUATION	$606,419
														Subtotal = $606,419

Issue Date FY: 2025 ( Subtotal = $604,860 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Oral Diseases and Disorders Research	001	4	5/8/2025	NON-COMPETING CONTINUATION	$60,486
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Oral Diseases and Disorders Research	000	4	4/1/2025	NON-COMPETING CONTINUATION	$544,374
														Subtotal = $604,860

Issue Date FY: 2024 ( Subtotal = $591,021 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Oral Diseases and Disorders Research	001	3	6/13/2024	NON-COMPETING CONTINUATION	$48,246
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Oral Diseases and Disorders Research	000	3	3/19/2024	NON-COMPETING CONTINUATION	$542,775
														Subtotal = $591,021

Issue Date FY: 2023 ( Subtotal = $601,493 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Oral Diseases and Disorders Research	000	2	3/22/2023	NON-COMPETING CONTINUATION	$601,493
														Subtotal = $601,493

Issue Date FY: 2022 ( Subtotal = $633,059 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Oral Diseases and Disorders Research	000	1	7/5/2022	NEW	$633,059
														Subtotal = $633,059

Grand Total All Awards = $3,036,852

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Precision imaging for risk stratification and personalized therapy of oropharyngeal cancer

Award Number: R01DE030894

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/05/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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