Tuesday, July 1, 2025 7/1/2025

DC exosome therapy to resolve inflammatory bone loss and oral infection

Award Number: R01DE029468
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/14/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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DC exosome therapy to resolve inflammatory bone loss and oral infection - Project Abstract Periodontitis (PD) is a bone degenerative inflammatory disease that contributes to increased risk of other diseases with more serious mortality and morbidity profiles. We propose here a novel immune therapeutic strategy for PD, using cellular nano-particles, exosomes (EXO) from dendritic cells. Dendritic cells are the “directors” of the adaptive immune response, as such, their immune functions can be exploited to treat chronic immune-mediated diseases such as cancer and autoimmune diseases. This is first study to our knowledge to employ phenotypically stable exosomes from dendritic cells to treat experimental PD in mice. Our strategy consists of “reprograming” immune cells in the periodontium responsible for destructive inflammatory bone loss using custom DC exo. Our tactic is to inject DC exo directly into the gingiva, to target anti-inflammatory pathways in specific immune cells, to prevent/resolve alveolar bone loss. The overall objective of these studies to acquire a better understanding of the immunobiology of DC-derived exo in vivo and in vitro in the murine model of experimental PD, and relate these findings to exo isolated from humans with PD. Our aims are to test the hypotheses that: Aim 1. Exogenous DCexo delivered to the PD lesion persist in situ and reprogram recipient DCs and T cells involved in experimental PD in mice in vivo; Aim 2. DC exo preserve molecular cargo and reprogram acceptor DCs and T cells through receptor binding and endocytosis; Aim 3. Endogenous exo from humans with PD contain molecular cargo of direct relevance to exo therapy and PD pathogenesis. Future goals include: 1. the development of DC exo therapy for PD in humans, 2. assessment of salivary exo molecular cargo for diagnostic potential in PD and other oral diseases


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $365,750 )
2025	2025	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	AUGUSTA UNIVERSITY 1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Oral Diseases and Disorders Research	000	5	5/21/2025	NON-COMPETING CONTINUATION	$365,750
														Subtotal = $365,750

Issue Date FY: 2024 ( Subtotal = $358,435 )
2024	2024	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	AUGUSTA UNIVERSITY 1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Oral Diseases and Disorders Research	001	4	4/12/2024	NON-COMPETING CONTINUATION	$329,175
2024	2024	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	AUGUSTA UNIVERSITY 1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Oral Diseases and Disorders Research	002	4	6/18/2024	NON-COMPETING CONTINUATION	$29,260
2024	2023	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	AUGUSTA UNIVERSITY 1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Oral Diseases and Disorders Research	000	3	3/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $358,435

Issue Date FY: 2023 ( Subtotal = $365,750 )
2023	2023	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Oral Diseases and Disorders Research	000	3	4/26/2023	NON-COMPETING CONTINUATION	$365,750
														Subtotal = $365,750

Issue Date FY: 2022 ( Subtotal = $362,093 )
2022	2022	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Oral Diseases and Disorders Research	000	2	4/27/2022	NON-COMPETING CONTINUATION	$362,093
														Subtotal = $362,093

Issue Date FY: 2021 ( Subtotal = $365,750 )
2021	2021	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Oral Diseases and Disorders Research	000	1	7/14/2021	NEW	$365,750
2021	2021	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Oral Diseases and Disorders Research	001	1	7/28/2021	NEW	$0
														Subtotal = $365,750

Grand Total All Awards = $1,817,778

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DC exosome therapy to resolve inflammatory bone loss and oral infection

Award Number: R01DE029468

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/14/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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